R935788 (Fostamatinib disodium, R788) CAS: 1025687-58-4
MF: C23H24FN6O9P.2Na
MW: 624.42
An inhibitor to spleenic kinase-mediated IgG Fc receptor signaling.

R935788 (Fostamatinib disodium, R788) (CAS 1025687-58-4)

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Alternate Names: R 788 sodium; FosD
Application R935788 (Fostamatinib disodium, R788) is an inhibitor to spleenic kinase-mediated IgG Fc receptor signaling
CAS 등록번호: 1025687-58-4
순도: ≥98%
분자량: 624.42
분자식: C23H24FN6O9P.2Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

R788 (Fostamatinib) is an important spleen tyrosine kinase (Syk) inhibitor, showing efficacy against kinase-mediated IgG Fc gamma receptor signaling. R788 inhibits the activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage. In one study, inhibition of BCR signaling with R788 affected the growth of certain leukemia cell lines. These leukemia cells express stereotyped BCRs that react with auto-antigens exposed on the surface of senescent or apoptotic cells, suggesting that they are antigen driven.

Appearance :
Powder
Physical State :
Solid
용해도 :
Soluble in DMSO (0.4 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), and 0.5% CMC/0.25% Tween 80,pH6.5 (30 mg/ml at 25 °C).
저장 :
Store at -20° C
굴절률 :
n20D ~1.63 (Predicted)
IC50 :
Syk: IC50 = 41 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
25008120
MDL Number :
MFCD15146370
SMILES :
CC1(C(=O)N(C2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)COP(=O)([O-])[O-])C.[Na+].[Na+]

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