PSMD11 Antibody (AT1F4): sc-517421
- PSMD11 Antibody (AT1F4) is a mouse monoclonal IgG1 κ PSMD11 antibody, cited in 1 publications, provided at 100 µg/ml
- raised against a recombinant protein corresponding to amino acids 1-422 of PSMD11 of human origin
- recommended for detection of PSMD11 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PSMD11 Antibody (AT1F4). This work is in progress.
PSMD11 Antibody (AT1F4) is a mouse monoclonal IgG1 kappa light chain antibody that detects PSMD11 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-PSMD11 antibody (AT1F4) is available as a non-conjugated format. PSMD11, also known as S9, Rpn6, or p44.5, is a crucial regulatory subunit of the 26S proteasome, which is essential for selective degradation of ubiquitinated proteins in eukaryotic cells. PSMD11 consists of 422 amino acids and features a PCI domain, playing a vital role in ATP-dependent degradation process that maintains cellular homeostasis by regulating protein turnover. The 26S proteasome consists of a 20S core particle that serves as the proteolytic chamber and two 19S regulatory particles that recognize and unfold ubiquitinated substrates, ensuring damaged or misfolded proteins are efficiently removed from cells. PSMD11 is encoded on human chromosome 17, a region encompassing over 2.5% of the human genome and responsible for encoding more than 1,200 genes, highlighting PSMD11′s importance in cellular function and potential implications in various diseases related to protein mismanagement.
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PSMD11 Antibody (AT1F4) References:
- MicroRNA-451 inhibits inflammation and proliferation of glomerular mesangial cells through down-regulating PSMD11 and NF-κB p65. | Wei, H., et al. 2019. Biosci Rep. 39: PMID: 31652441
- The effect and mechanism of 19S proteasome PSMD11/Rpn6 subunit in D-Galactose induced mimetic aging models. | Wu, H., et al. 2020. Exp Cell Res. 394: 112093. PMID: 32450067
- PSMD11, PTPRM and PTPRB as novel biomarkers of pancreatic cancer progression. | Sahni, S., et al. 2020. Biochim Biophys Acta Gen Subj. 1864: 129682. PMID: 32663515
- Relationship between the Expression Level of PSMD11 and Other Proteasome Proteins with the Activity of Ricin and Viscumin. | Maltseva, DV., et al. 2020. Dokl Biochem Biophys. 493: 198-200. PMID: 32894464
- Long-noncoding RNA Peg13 alleviates epilepsy progression in mice via the miR-490-3p/Psmd11 axis to inactivate the Wnt/β-catenin pathway. | Feng, H., et al. 2020. Am J Transl Res. 12: 7968-7981. PMID: 33437373
- PSMD11 modulates circadian clock function through PER and CRY nuclear translocation. | Cal-Kayitmazbatir, S., et al. 2023. PLoS One. 18: e0283463. PMID: 36961772
- An integrative analysis reveals the prognostic value and potential functions of PSMD11 in hepatocellular carcinoma. | Zhang, C., et al. 2023. Mol Carcinog. 62: 1355-1368. PMID: 37212487
- Identification of PSMD11 as a novel cuproptosis- and immune-related prognostic biomarker promoting lung adenocarcinoma progression. | Huang, Q., et al. 2024. Cancer Med. 13: e7379. PMID: 38859698
- PSMD11 promotes the proliferation of hepatocellular carcinoma by regulating the ubiquitination degradation of CDK4. | Sun, L., et al. 2024. Cell Signal. 121: 111279. PMID: 38944255
- Prognostic value and potential biological function of PMSD11 in lung adenocarcinoma. | Xi, Y., et al. 2024. J Thorac Dis. 16: 7819-7835. PMID: 39678883
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PSMD11 Antibody (AT1F4) | sc-517421 | 100 µg/ml | $322.00 |