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Prazosin hydrochloride (CAS 19237-84-4)

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Application:
Prazosin hydrochloride is an andrenergic α1, α2B-adrenoceptor, & MT3 receptor antagonist
CAS Number:
19237-84-4
Purity:
≥98%
Molecular Weight:
419.87
Molecular Formula:
C19H21N5O4•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Prazosin hydrochloride, is a hydrochloride salt of prazosin, this compound exhibits enhanced solubility in water, which is a critical feature for various experimental applications. Its structure consists of a quinazoline backbone attached to a furan ring and a piperazine ring, each contributing distinct chemical characteristics. The compound′s mechanism of action is rooted in its ability to interact with specific receptors and proteins, a feature that is often harnessed in biochemical and pharmacological research to understand receptor-ligand interactions and signaling pathways. Furthermore, its role in modulating the behavior of certain receptors has been instrumental in studying the structural and functional aspects of these receptors. In analytical chemistry, prazosin hydrochloride serves as a reference compound for chromatographic and spectroscopic analyses, aiding in the development of analytical methods and the understanding of complex chemical behaviors. Its stability and distinct spectroscopic properties make it suitable for various analytical techniques, including mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy.


Prazosin hydrochloride (CAS 19237-84-4) References

  1. Characterization of 2-[125I]iodomelatonin binding sites in Syrian hamster peripheral organs.  |  Paul, P., et al. 1999. J Pharmacol Exp Ther. 290: 334-40. PMID: 10381796
  2. Enhancer aided in vitro permeation of atenolol and prazosin hydrochloride through mice skin.  |  Reddy, LH. and Ghosh, B. 2001. Indian J Exp Biol. 39: 47-51. PMID: 11349525
  3. Sensitive fluorimetric method based on sequential injection analysis technique used for dissolution studies and quality control of prazosin hydrochloride in tablets.  |  Legnerová, Z., et al. 2004. J Pharm Biomed Anal. 34: 115-21. PMID: 14738925
  4. Structural characterization of prazosin hydrochloride and prazosin free base.  |  Chernyshev, VV., et al. 2004. J Pharm Sci. 93: 3090-5. PMID: 15514987
  5. Preparation and characterization of inclusion complexes of prazosin hydrochloride with beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin.  |  Liu, L. and Zhu, S. 2006. J Pharm Biomed Anal. 40: 122-7. PMID: 16095859
  6. Delivery of prazosin hydrochloride from osmotic pump system prepared by coating the core tablet with an indentation.  |  Liu, L., et al. 2007. Drug Deliv. 14: 219-24. PMID: 17497354
  7. Individual differences in the effects of chronic prazosin hydrochloride treatment on hippocampal mineralocorticoid and glucocorticoid receptors.  |  Kabbaj, M., et al. 2007. Eur J Neurosci. 25: 3312-8. PMID: 17552999
  8. Interpenetrating network hydrogel membranes of sodium alginate and poly(vinyl alcohol) for controlled release of prazosin hydrochloride through skin.  |  Kulkarni, RV., et al. 2010. Int J Biol Macromol. 47: 520-7. PMID: 20678518
  9. Pharmacological characterization of melatonin binding sites in Syrian hamster hypothalamus.  |  Pickering, DS. and Niles, LP. 1990. Eur J Pharmacol. 175: 71-7. PMID: 2157597
  10. Effect of counterion on the solid state photodegradation behavior of prazosin salts.  |  Kumar, L., et al. 2013. AAPS PharmSciTech. 14: 757-63. PMID: 23595416
  11. Preparation and transdermal diffusion evaluation of the prazosin hydrochloride-loaded electrospun poly(vinyl alcohol) fiber mats.  |  Shen, X., et al. 2014. J Nanosci Nanotechnol. 14: 5258-65. PMID: 24758013
  12. Determination of terazosin in the presence of prazosin: Different state-of-the-art machine learning algorithms with UV spectroscopy.  |  Ibrahim, AM., et al. 2020. Spectrochim Acta A Mol Biomol Spectrosc. 236: 118349. PMID: 32305835
  13. Prazosin as initial antihypertensive therapy: correlates of sympathetic function.  |  Guthrie, GP., et al. 1984. Am J Cardiol. 53: 29A-31A. PMID: 6695763
  14. Disparate effects of prazosin and propranolol on lipid metabolism in a rat model.  |  Dall'Aglio, E., et al. 1983. Metabolism. 32: 510-3. PMID: 6843362
  15. Prazosin inhibits MK-801-induced hyperlocomotion and dopamine release in the nucleus accumbens.  |  Mathé, JM., et al. 1996. Eur J Pharmacol. 309: 1-11. PMID: 8864686

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Prazosin hydrochloride, 100 mg

sc-204858
100 mg
$94.00