PPIase-Parvulin 억제제 CAS: 64005-90-9
MF: C22H18N2O8
MW: 438.4
A Pin1/Pin4 PPIase activity inhibitor.

PPIase-Parvulin 억제제 (CAS 64005-90-9)

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Alternate Names: PiB; HIC 016C; Diethyl-1,3,6,8-tetrahydro-1,3,6,8-tetraoxobenzo[lmn][3,8]phenanthroline-2,7-diacetate
Application PPIase-Parvulin Inhibitor is a Pin1/Pin4 PPIase activity inhibitor
CAS 등록번호: 64005-90-9
순도: ≥95%
분자량: 438.4
분자식: C22H18N2O8
추가 정보: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* 참조분석증명서대량의 측정 데이터(함수량포함).

PPIase-Parvulin Inhibitor is a cell-permeable napthalenetetracarboxylic-bisimide compound that displays anti-proliferative properties. PPIase-Parvulin Inhibitor causes cell cycle arrest and acts as a potent, competitive, selective, reversible, active site binding inhibitor of Pin1/Pin4 PPIase (peptidyl prolyl cis-trans isomerase) activity. It does not bind to DNA or functions as a topoisomerase I inhibitor.


References

1. Uchida, Takafumi., et al., 2003. Pin1 and Par14 peptidyl prolyl isomerase inhibitors block cell proliferation. Chemistry & biology. 10(1): 15-24. PMID: 12573694

Physical State :
Solid
용해도 :
Soluble in chloroform (1 mg/ml), and ethanol (250 µg/ml, cloudy suspension).
저장 :
Store at 4° C
녹는점 :
>300° C
비등점 :
636.46° C at 760 mmHg (Predicted)
밀도 :
1.47 g/cm3 (Predicted)
굴절률 :
n20D 1.64 (Predicted)
IC50 :
Pin1/Par14 PPIase : IC50 = ~ 1.5 µM
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
Transport :
UN 3077, Class 9, Packing group III
PubChem CID :
SMILES :
CCOC(=O)CN1C(=O)C2=C3C(=CC=C4C3=C(C=C2)C(=O)N(C4=O)CC(=O)OCC)C1=O

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