PlGF Antibody (H-4): sc-518003

PlGF Antibody (H-4) is a mouse monoclonal IgA kappa light chain antibody that detects PlGF, specifically the PIGF-1, PIGF-3, and to a lesser extent, PIGF-2 isoforms, in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-PlGF antibody (H-4) is available in a non-conjugated form, allowing for versatile experimental use. The placenta growth factor (PlGF) plays a crucial role in angiogenesis, which is the formation of new blood vessels, a process vital for normal physiological functions as well as pathological conditions like cancer. PlGF is primarily secreted by placental trophoblasts and is involved in the regulation of endothelial cell proliferation and migration, making PlGF a significant factor in tumor progression and metastasis. Notably, PlGF interacts with the vascular endothelial growth factor (VEGF) signaling pathway, where PlGF can enhance the effects of VEGF, particularly in the context of tumor microenvironments. The ability of PlGF to form homodimers and heterodimers with VEGF underscores PlGF′s importance in mediating angiogenic responses, and PlGF′s interaction with the Flt-1 receptor further highlights PlGF′s role in vascular biology. Understanding the function and mechanisms of PlGF is essential for developing therapeutic strategies targeting angiogenesis in various diseases, including cancer.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PlGF Antibody (H-4) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-PlGF Antibody (H-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PlGF Antibody (H-4) Specifications

Alternate Product Name: PlGF

Product Clone Name: H-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgA kappa light chain

Amino Acids: 124-149

Epitope Target: PlGF

Epitope Species: human

Product Reactivity/Detection: PIGF-1, PIGF-3 and to a lesser extent, PIGF-2 isoforms

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgA kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for PlGF Antibody (H-4): N/A