human origin의 PGRP-L에서 N-terminus에 위치한 22-321 아미노산을 항원으로 사용하였습니다.
안티-PGRP-L 항체 (B-4)는 WB, IP, IF, IHC(P) and ELISA으로 mouse, rat and human유래의 PGRP-L 를 감지하는 데에 추천한다.
IP를 위해 agarose ;WB, IHC(P) and ELISA를 위해 HRP ;또는 IF, IHC(P) and FCM를 위해 phycoerythrin or FITC 에 결합된 Anti-PGRP-L 항체 (B-4)를 제공한다.
WB (RGB), IF, IHC(P) 와FCM, RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems에 사용가능한 Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647결합제품도 있습니다.
WB (NIR), IF와FCM,Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems에 사용가능한 Alexa Fluor® 680 or Alexa Fluor® 790 결합제품도 있습니다.
m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PGRP-L Antibody (B-4) for WB and IHC(P) applications. These reagents are now offered in bundles with PGRP-L Antibody (B-4) (see ordering information below).
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PGRP-L Antibody (B-4) is a high quality monoclonal PGRP-L antibody (also designated PGRP-L antibody) suitable for the detection of the PGRP-L protein of mouse, rat and human origin. PGRP-L Antibody (B-4) is available as both the non-conjugated anti-PGRP-L antibody form, as well as multiple conjugated forms of anti-PGRP-L antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Peptidoglycan recognition protein-L (PGRP-L) is a pattern recognition molecule consisting of 576 amino acid residues. It is the longest and most widely expressed member of the PGRP family. PGRP-L is a Zn2+-dependent protein with N-acetylmuramyl-L-alanine-amidase activity that digests peptidoglycan. PGRP-L can form a homodimer and may dimerize with other PGRP proteins. It is a secreted serum protein but is also expressed as a transmembrane protein in liver parenchymal cells binding peptidoglycan and Gram-positive bacteria. PGRP-L deficient mice exhibit slightly lower levels of IL-6 and TNFα but exhibit no obvious phenotypic abnormalities. This suggests that PGRP-L may play a minor role in innate immune functions. In addition, PGRP-L may be a key player in the activation of Nod1, an intracellular pattern recognition protein.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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