Molecular structure of PD-146176, CAS Number: 4079-26-9
PD-146176 (CAS 4079-26-9)
See product citations (9)
Alternate Names:
6,11-Dihydro[1]benzothiopyrano[4,3-b]indole
Application:
PD-146176 is a potent and selective 15-LO inhibitor
CAS Number:
4079-26-9
Purity:
≥98%
Molecular Weight:
237.3
Molecular Formula:
C15H11NS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PD-146176 is a potent and selective inhibitor of 15-LO that suppresses oxidant stress-induced apoptosis in endothelial cells. Studies indicate that PD-146176 reduces atherosclerotic lesion development in New Zealand white rabbit through its nonspecific antioxidant properties. It is known that PD-146176 acts as a noncompetitive inhibitor towards 15-LO, displaying a Ki=197 nM. Furthermore, PD-146176 reduces monocyte macrophage enrichment of atherosclerotic lesions and development of fibrofoamy and fibrous plaque.
PD-146176 (CAS 4079-26-9) References
- Overexpression of 15-lipoxygenase-1 in PC-3 human prostate cancer cells increases tumorigenesis. | Kelavkar, UP., et al. 2001. Carcinogenesis. 22: 1765-73. PMID: 11698337
- Enhanced 15-HPETE production during oxidant stress induces apoptosis of endothelial cells. | Sordillo, LM., et al. 2005. Prostaglandins Other Lipid Mediat. 76: 19-34. PMID: 15967159
- Lipoxin biosynthesis in inflammatory bowel disease. | Mangino, MJ., et al. 2006. Prostaglandins Other Lipid Mediat. 79: 84-92. PMID: 16516812
- A role for 12/15 lipoxygenase in the amyloid beta precursor protein metabolism. | Succol, F. and Praticò, D. 2007. J Neurochem. 103: 380-7. PMID: 17877641
- 15-lipoxygenase metabolites play an important role in the development of a T-helper type 1 allergic inflammation induced by double-stranded RNA. | Jeon, SG., et al. 2009. Clin Exp Allergy. 39: 908-17. PMID: 19260872
- Arachidonic acid epoxygenase and 12(S)-lipoxygenase: evidence of their concerted involvement in ductus arteriosus constriction to oxygen. | Baragatti, B. and Coceani, F. 2011. Can J Physiol Pharmacol. 89: 329-34. PMID: 21619415
- Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses. | Ou, Y., et al. 2016. Proc Natl Acad Sci U S A. 113: E6806-E6812. PMID: 27698118
- On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death. | Zilka, O., et al. 2017. ACS Cent Sci. 3: 232-243. PMID: 28386601
- In Vitro Effects of Selective COX and LOX Inhibitors and Their Combinations with Antineoplastic Drugs in the Mouse Melanoma Cell Line B16F10. | Da-Costa-Rocha, I. and Prieto, JM. 2021. Int J Mol Sci. 22: PMID: 34204367
- Activation of SSAT1/ALOX15 Axis Aggravates Cerebral Ischemia/Reperfusion Injury via Triggering Neuronal Ferroptosis. | Zhao, J., et al. 2022. Neuroscience. 485: 78-90. PMID: 35090880
- PD146176 affects human EA.hy926 endothelial cell function by differentially modulating oxylipin production of LOX, COX and CYP epoxygenase. | Du, Y., et al. 2022. Biochim Biophys Acta Mol Cell Biol Lipids. 1867: 159156. PMID: 35367352
- Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties. | Sendobry, SM., et al. 1997. Br J Pharmacol. 120: 1199-206. PMID: 9105693
- A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit. | Bocan, TM., et al. 1998. Atherosclerosis. 136: 203-16. PMID: 9543090
Inhibitor of:
15-LO.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PD-146176, 10 mg | sc-200678 | 10 mg | $124.00 | |||
PD-146176, 50 mg | sc-200678A | 50 mg | $455.00 |