human origin의 Paip2에서 에 가까운65-97의 아미노산사이에 위치한 항원결정부와 특정결합합니다.
Paip2 항체 (C-8)는 WB, IP, IF, IHC(P) and ELISA으로mouse, rat, human and avian유래의 Paip2 를 감지하는 데에 추천한다 ; 이외에, equine, canine, bovine, porcine and avian등 species와 반응할수 있습니다
IP를 위해 agarose ;WB, IHC(P) and ELISA를 위해 HRP ;또는 IF, IHC(P) and FCM를 위해 phycoerythrin or FITC 에 결합된 Anti-Paip2 항체 (C-8)를 제공한다.
WB (RGB), IF, IHC(P) 와FCM, RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems에 사용가능한 Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647결합제품도 있습니다.
WB (NIR), IF와FCM,Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems에 사용가능한 Alexa Fluor® 680 or Alexa Fluor® 790 결합제품도 있습니다.
m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Paip2 Antibody (C-8) for WB and IHC(P) applications. These reagents are now offered in bundles with Paip2 Antibody (C-8) (see ordering information below).
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
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SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Paip2 Antibody (C-8) is a high quality monoclonal Paip2 antibody (also designated Paip2 antibody) suitable for the detection of the Paip2 protein of mouse, rat and human origin. Paip2 Antibody (C-8) is available as both the non-conjugated anti-Paip2 antibody form, as well as multiple conjugated forms of anti-Paip2 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Paip, for PABP-interacting protein, binds to the polyadenylate-binding protein (PABP). There are two Paip proteins called Paip1 and Paip2. Paip1 stimulates translation, and Paip2, which competes with Paip1 for binding to PABP, represses translation. Paip1 contains a region similar to the central portion of eIF4G. Paip2 decreases the affinity of PABP for polyadenylate RNA, and disrupts the repeating structure of poly(A) ribonucleoprotein. Paip2 contains two binding sites for PABP, one encompassing a 16-amino-acid stretch located in the C terminus and a second encompassing a larger central region. There is a two-to-one stoichiometry for binding of Paip2 to PABP indicating that they could form a trimeric complex containing one PABP molecule and two Paip2 molecules. Significantly, only the central Paip2 fragment, which binds with high affinity to the PABP RRM region, inhibits PABP binding to poly(A) RNA and translation. Translation in extracts in which elF4G is cleaved is resistant to inhibition by Paip2. The human Paip2 gene maps to chromosome 5q31 and encodes a 127 amino acid protein.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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