OPN1SW Antibody (1B10): sc-517304

OPN1SW Antibody (1B10) is a mouse monoclonal IgG2b kappa light chain antibody that detects the OPN1SW protein of human origin by western blotting (WB). Anti-OPN1SW antibody (1B10) is available as the non-conjugated format. OPN1SW, also known as blue-sensitive opsin, plays a pivotal role in human color vision by mediating the perception of blue light through its function in the cone cells of the retina. OPN1SW is primarily located in the photoreceptor cells of the retina, where OPN1SW is essential for the phototransduction process, converting light into electrical signals that the brain interprets as visual information. The precise localization of OPN1SW in the cone cells is crucial, as OPN1SW allows for the differentiation of colors, particularly in the blue spectrum, which is vital for normal color perception. The interaction of OPN1SW with the retinaldehyde chromophore enables absorption of light at specific wavelengths, and any disruption in this localization or function can lead to color vision deficiencies. Mutations in the gene encoding OPN1SW have been linked to various forms of color blindness, underscoring OPN1SW′s importance not only in visual acuity but also in the broader context of understanding and potentially treating color vision disorders.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

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OPN1SW Antibody (1B10) References:

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9. Tritan color vision deficiency may be associated with an OPN1SW splicing defect and haploinsufficiency.  |  Neitz, M., et al. 2020. J Opt Soc Am A Opt Image Sci Vis. 37: A26-A34. PMID: 32400513
10. Gene Therapy in Opn1mw-/-/Opn1sw-/- Mice and Implications for Blue Cone Monochromacy Patients with Deletion Mutations.  |  Ma, X., et al. 2022. Hum Gene Ther. 33: 708-718. PMID: 35272502
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