Molecular structure of Omi/HtrA2 Protease Inhibitor, Ucf-101, CAS Number: 313649-08-0
Omi/HtrA2 Protease Inhibitor, Ucf-101 (CAS 313649-08-0)
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Application:
Omi/HtrA2 Protease Inhibitor, Ucf-101 is a cell-permeable furfurylidine-thiobarbituric acid
CAS Number:
313649-08-0
Purity:
≥97%
Molecular Weight:
495.5
Molecular Formula:
C27H17N3O5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Omi/HtrA2 Protease Inhibitor, Ucf-101 is a cell-permeable furfurylidine-thiobarbituric acid compound that acts as a potent, specific, competitive, and reversible inhibitor of the pro-apoptotic, heat-inducible, mitochondrial serine protease Omi/HtrA2 (IC50 = 9.5 muM for His-Omi134-458). Shows very little activity against various other serine proteases tested (IC50 ≥ 200 muM). Reported to block Omi/HtrA2 induced cell death in caspase-9 (-/-) null fibroblasts.
Omi/HtrA2 Protease Inhibitor, Ucf-101 (CAS 313649-08-0) References
- Characterization of a novel and specific inhibitor for the pro-apoptotic protease Omi/HtrA2. | Cilenti, L., et al. 2003. J Biol Chem. 278: 11489-94. PMID: 12529364
- [Effects of Ucf-101 on expression of Omi/HtrA2 in kidneys of postasphyxial neonatal rats]. | Hua, B., et al. 2010. Zhongguo Dang Dai Er Ke Za Zhi. 12: 658-61. PMID: 20704803
- Variations in the protein level of Omi/HtrA2 in the heart of aged rats may contribute to the increased susceptibility of cardiomyocytes to ischemia/reperfusion injury and cell death : Omi/HtrA2 and aged heart injury. | Wang, K., et al. 2013. Age (Dordr). 35: 733-46. PMID: 22535253
- Ucf-101 protects against cerebral oxidative injury and cognitive impairment in septic rat. | Hu, Y., et al. 2013. Int Immunopharmacol. 16: 108-13. PMID: 23557966
- Upregulation of mitochondrial protease HtrA2/Omi contributes to manganese-induced neuronal apoptosis in rat brain striatum. | Jiang, JK., et al. 2014. Neuroscience. 268: 169-79. PMID: 24657776
- Acute administration of ucf-101 ameliorates the locomotor impairments induced by a traumatic spinal cord injury. | Reigada, D., et al. 2015. Neuroscience. 300: 404-17. PMID: 26004679
- Protection Against Cold Storage-Induced Renal Tubular Cell Apoptosis. | Jain, S., et al. 2015. Transplantation. 99: 2311-6. PMID: 26177086
- Protease Omi facilitates neurite outgrowth in mouse neuroblastoma N2a cells by cleaving transcription factor E2F1. | Ma, Q., et al. 2015. Acta Pharmacol Sin. 36: 966-75. PMID: 26238290
- Protease Omi cleaving Hax-1 protein contributes to OGD/R-induced mitochondrial damage in neuroblastoma N2a cells and cerebral injury in MCAO mice. | Wu, JY., et al. 2015. Acta Pharmacol Sin. 36: 1043-52. PMID: 26299953
- Protective Effects of UCF-101 on Cerebral Ischemia-Reperfusion (CIR) is Depended on the MAPK/p38/ERK Signaling Pathway. | Su, D., et al. 2016. Cell Mol Neurobiol. 36: 907-914. PMID: 26429193
- Cardiac Specific Overexpression of Mitochondrial Omi/HtrA2 Induces Myocardial Apoptosis and Cardiac Dysfunction. | Wang, K., et al. 2016. Sci Rep. 6: 37927. PMID: 27924873
- Mitochondrial Omi/HtrA2 Promotes Caspase Activation Through Cleavage of HAX-1 in Aging Heart. | Liu, X., et al. 2017. Rejuvenation Res. 20: 183-192. PMID: 27998213
- Regulation of HtrA2 on WT1 gene expression under imatinib stimulation and its effects on the cell biology of K562 cells. | Zhang, L., et al. 2017. Oncol Lett. 14: 3862-3868. PMID: 28927158
- YoTube: Searching Action Proposal Via Recurrent and Static Regression Networks. | Zhu, H., et al. 2018. IEEE Trans Image Process. 27: 2609-2622. PMID: 29533898
- Learning to Recognize Actions From Limited Training Examples Using a Recurrent Spiking Neural Model. | Panda, P. and Srinivasa, N. 2018. Front Neurosci. 12: 126. PMID: 29551962
Inhibitor of:
Apoptosis, caspase-8, ENDOG, HtrA2, PARL, and Protease.Activator of:
SERHL.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Omi/HtrA2 Protease Inhibitor, Ucf-101, 10 mg | sc-222101 | 10 mg | $200.00 |