NT5C1A Antibody (C-9): sc-377244

NT5C1A Antibody (C-9) is a mouse monoclonal IgM antibody that detects NT5C1A protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-NT5C1A antibody (C-9) is available as the non-conjugated form. NT5C1A protein, also known as 5′-nucleotidase cytosolic 1A, consists of 365 amino acids and belongs to the 5′-nucleotidase type 3 family. NT5C1A plays a crucial role in nucleotide metabolism by catalyzing deoxyribonucleotide dephosphorylation, which maintains cellular nucleotide pools and regulates adenosine levels, particularly during heart ischemia and hypoxia. NT5C1A requires magnesium and water for activity and is activated by ADP, highlighting NT5C1A′s importance in cellular energy homeostasis and signaling. NT5C1A primarily localizes in the cytoplasm, exhibiting broad substrate specificity and participating in various metabolic pathways. NT5C1A′s encoding gene resides on chromosome four, notable for containing numerous genes and protein-coding sequence-devoid regions called gene deserts. Understanding NT5C1A′s function and regulation is vital for exploring cardiovascular health and disease, making NT5C1A (C-9) antibody an invaluable research tool.

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NT5C1A Antibody (C-9) References:

1. Gene structure and evolution of testicular haploid germ cell-specific genes, Oxct2a and Oxct2b.  |  Onishi, M., et al. 2004. Genomics. 83: 647-57. PMID: 15028287
2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4.  |  Hillier, LW., et al. 2005. Nature. 434: 724-31. PMID: 15815621
3. Recent advances in structure and function of cytosolic IMP-GMP specific 5'-nucleotidase II (cN-II).  |  Ipata, PL. and Tozzi, MG. 2006. Purinergic Signal. 2: 669-75. PMID: 18404470
4. Expression of cytosolic 5' nucleotidase does not correlate with expression of oxidative metabolism marker: myoglobine in human skeletal muscles.  |  Lechward, K. and Tkacz-Stachowska, K. 2009. Acta Biochim Biophys Sin (Shanghai). 41: 280-4. PMID: 19352542
5. Rosuvastatin increases extracellular adenosine formation in humans in vivo: a new perspective on cardiovascular protection.  |  Meijer, P., et al. 2009. Arterioscler Thromb Vasc Biol. 29: 963-8. PMID: 19359665

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-NT5C1A Antibody (C-9) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-NT5C1A Antibody (C-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

NT5C1A Antibody (C-9) Specifications

Alternate Product Name: NT5C1A

Product Clone Name: C-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 163-195

Epitope Target: NT5C1A

Epitope Species: human

Product Reactivity/Detection: NT5C1A

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine and canine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for NT5C1A Antibody (C-9): P: Blocking Peptide