NSC 95397 CAS: 93718-83-3
MF: C14H14O4S2
MW: 310.38
A quinone-based Cdc25 inhibitor, caspase-3 activator, ERK activator, and MKP inhibitor.

NSC 95397 (CAS 93718-83-3)

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Alternate Names: 2,3-bis(2-hydroxyethylsulfanyl)-(1,4)naphthoquinone
Application NSC 95397 is a quinone-based Cdc25 inhibitor, caspase-3 activator, ERK activator, and MKP inhibitor
CAS 등록번호: 93718-83-3
순도: >97%
분자량: 310.38
분자식: C14H14O4S2
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* 참조분석증명서대량의 측정 데이터(함수량포함).

NSC 95397 is a selective and effective dual-specificity, quinone-based phosphatase inhibitor. The compound has been reported to inhibit Cdc25A, B and C, and is more selective than VH1-related dual-specificity phosphatase or protein tyrosine phosphatase 1b. Cdc25A is a phosphatase vital for the progression of the cell cycle and NSC 95397 has been noted to inhibit the G2/M phase transition and cell growth. NSC 95397 has demonstrated the ability to activate ERK-1 and ERK-2, induce tyrosine phosphorylation of EGFR, activate caspase-3, and inhibit MKP-1 and MKP-3.


References

1. Lazo, J.S., et al. 2002. Mol. Pharmacol. 61: 720-728. PMID: 11901209
2. Han, Y., et al. 2004. J. Pharmacol. Exp. Ther. 309: 64-70. PMID: 14718602
3. Melchheier, I., et al. 2005. Biochem. Biophys. Res. Commun. 327: 1016-1023. PMID: 15652497
4. Vogt, A., et al. 2008. Mol. Cancer Ther. 7: 330-340. PMID: 18245669
5. Larsson, D.E., et al. 2010. Anticancer Res. 30: 149-156. PMID: 20150630

Physical State :
Solid
용해도 :
Soluble in DMSO (16 mg/ml), ethanol (5 mM), and DMSO (50 mM).
저장 :
Store at -20° C
비등점 :
499.16° C at 760 mmHg
밀도 :
1.46 g/cm3
굴절률 :
n20D 1.68
IC50 :
Large T antigen: EC5050 = 28240 nM (Simian virus 40); Dual specificity phosphatase Cdc25C: IC50 = 56.9 nM (human); CHO (Ovarian cells): IC50 = 479.38 nM (Cricetulus griseus); Dual specificity phosphatase Cdc25B: IC50 = 100 nM (human); Toll-like receptor 9: IC50 = 1869 nM (human); recombinant human Cdc25B: IC50 = <500 nM
Ki 데이타 :
Cdc25A: Ki= 32 nM; Cdc25B: Ki= 96 nM; Cdc25C: Ki= 40 nM
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD04040032
SMILES :
C1=CC=C2C(=C1)C(=O)C(=C(C2=O)SCCO)SCCO

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NSC 95397 (CAS 93718-83-3)  논문정보

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PMID: # 31499005  Bailey, KA.|Moreno, E.|Haj, FG.|Simon, SI.|Passerini, AG.| et al. 2019. FASEB J. 33: 12888-12899.

PMID: # 29540535  Yu, CH. et al. 2018. Biosci. Rep. 38:

PMID: # 29041978  Peng, WX. et al. 2017. Mol. Cancer. 16: 161.

PMID: # 26859151  Boulding, T. et al. 2016. PloS one. 11: e0148065.

PMID: # 19269962  Panchal, RG. et al. 2009. J. Biol. Chem. 284: 12874-12885.

PMID: # 18245669  Vogt, A. et al. 2008. Mol. Cancer Ther. 7: 330-340.

PMID: # 11901209  Lazo, JS. et al. 2002. Mol. Pharmacol. 61: 720-728.

PMID: # 32616888  Oncogene.

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