MYH7 Antibody (A4.840): sc-53089

MYH7 Antibody (A4.840) is a mouse monoclonal IgM antibody that detects the MYH7 protein of mouse, rat, human, rabbit, and avian origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-MYH7 antibody (A4.840) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MYH7, also known as myosin heavy chain beta, plays a crucial role in muscle contraction and is primarily expressed in cardiac and slow-twitch skeletal muscle fibers. MYH7′s structure is essential for function, forming a heterohexamer with two heavy chains and two pairs of light chains, allowing for the generation of force and movement through ATP hydrolysis. Proper functioning of MYH7 is vital for maintaining cardiac muscle integrity, and mutations in the MYH7 gene are linked to hypertrophic cardiomyopathy, a condition that can lead to serious heart complications. MYH7 (A4.840) antibody enables researchers to gain insights into the molecular mechanisms underlying muscle function and the pathophysiology of related diseases.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

MYH7 Antibody (A4.840) References:

1. The contribution of mutations in MYH7 to the onset of cardiomyopathy.  |  Bollen, IAE. and van der Velden, J. 2017. Neth Heart J. 25: 653-654. PMID: 29052809
2. MYH7 mutation associated with two phenotypes of myopathy.  |  Li, N., et al. 2018. Neurol Sci. 39: 333-339. PMID: 29170849
3. Hypertrophic cardiomyopathy MYH7 mutation R723G alters mRNA secondary structure.  |  Rose, J., et al. 2020. Physiol Genomics. 52: 15-19. PMID: 31790337
4. Generation of a homozygous MYH7 gene knockout human embryonic stem cell line (WAe009-A-69) using an episomal vector-based CRISPR/Cas9 system.  |  Guo, T., et al. 2021. Stem Cell Res. 57: 102566. PMID: 34678661
5. Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model.  |  Xia, Y., et al. 2022. J Vis Exp.. PMID: 35993750
6. Electrophysiological Characterization of a MYH7 Variant with Tremor Phenotype.  |  Vial, F., et al. 2023. Mov Disord Clin Pract. 10: 646-651. PMID: 37070061
7. [Recent research on childhood hypertrophic cardiomyopathy caused by MYH7 gene mutations].  |  Zheng, K., et al. 2023. Zhongguo Dang Dai Er Ke Za Zhi. 25: 425-430. PMID: 37073850
8. MYH7 p.(Arg1712Gln) is pathogenic founder variant causing hypertrophic cardiomyopathy with overall relatively delayed onset.  |  Marsili, L., et al. 2023. Neth Heart J. 31: 300-307. PMID: 37488328
9. Multiplexed Functional Assessments of MYH7 Variants in Human Cardiomyocytes.  |  Friedman, CE., et al. 2024. Circ Genom Precis Med. 17: e004377. PMID: 38362799
10. A MYH7 variant in a five-generation-family with hypertrophic cardiomyopathy.  |  Franke, M., et al. 2024. Front Genet. 15: 1306333. PMID: 38389574

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MYH7 Antibody (A4.840) has 37 citations in a variety of scientific publications.

Primary antibodies like Anti-MYH7 Antibody (A4.840) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MYH7 Antibody (A4.840) Specifications

Alternate Product Name: MYH7

Product Clone Name: A4.840

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids:

Epitope Target: adult skeletal muscle myosin

Epitope Species: human

Product Reactivity/Detection: myosin heavy chain 7

Species Reactivity/Detection: mouse, rat, human, rabbit, avian

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 37 citations in various scientific publications

Available Conjugates/Forms for MYH7 Antibody (A4.840): AC: Agarose, AF488: Alexa Fluor^® 488, AF647: Alexa Fluor^® 647, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred MYH7 antibody is MYH7 Antibody (A4.951): sc-53090.