Date published: 2026-4-29

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Methyl acetoacetate sodium salt (CAS 34284-28-1)

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Alternate Names:
Sodium methyl acetoacetate
Application:
Methyl acetoacetate sodium salt is used in alkylation reactions and chromatography applications
CAS Number:
34284-28-1
Molecular Weight:
138.10
Molecular Formula:
C5H7NaO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Methyl acetoacetate sodium salt is a sodium derivative of methyl acetoacetate, widely utilized in various research applications primarily due to its role as a chemical reagent. This compound is particularly valued in synthetic chemistry for its efficacy in facilitating the synthesis of heterocyclic compounds, which are core structures in many complex organic molecules. The sodium ion in this salt enhances its solubility in water, making it more suitable for reactions that require aqueous conditions. This characteristic is in promoting more efficient and diverse chemical reactions, thereby expanding the scope of possible synthetic pathways. Methyl acetoacetate sodium salt is also instrumental in the preparation of Michael acceptors, serving as a key component in Michael reactions – a method extensively used to form carbon-carbon bonds in an efficient and controllable manner. This makes it an indispensable tool in the development of new materials and in the study of reaction mechanisms, helping to advance the understanding of chemical processes at a molecular level.


Methyl acetoacetate sodium salt (CAS 34284-28-1) References

  1. Stereospecific substitution of enantiomerically pure 1-(2-pyridinyl)ethyl methanesulfonate with beta-dicarbony compounds.  |  Uenishi, J. and Hamada, M. 2002. Chem Pharm Bull (Tokyo). 50: 697-700. PMID: 12036035
  2. Domino Michael-Aldol reactions on 1,4-diarylbut-2-ene-1,4-diones with methyl acetoacetate furnish methyl 2-aroyl-4- hydroxy-6-oxo-4-arylcyclohexane-1-carboxylate derivatives.  |  Rao, HS. and Senthilkumar, SP. 2004. J Org Chem. 69: 2591-4. PMID: 15049666
  3. Investigation of the mechanism for the preparation of 6-phenyl-2,4-dioxotetrahydropyrans by the potassium carbonate promoted condensation between acetoacetate esters and benzaldehyde.  |  Andersh, B., et al. 2013. J Org Chem. 78: 4563-7. PMID: 23551266
  4. Design, Synthesis, and Antifungal Activities of 3-Acyl Thiotetronic Acid Derivatives: New Fatty Acid Synthase Inhibitors.  |  Lv, P., et al. 2018. J Agric Food Chem. 66: 1023-1032. PMID: 29290106
  5. A novel NADH-dependent carbonyl reductase with an extremely broad substrate range from Candida parapsilosis: purification and characterization.  |  Peters, J., et al. 1993. Enzyme Microb Technol. 15: 950-8. PMID: 7764255

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Methyl acetoacetate sodium salt, 100 g

sc-228566
100 g
$56.00