Megestrol Acetate (CAS 595-33-5)

모습 :

Powder

건강 상태 :

Solid

용해도 :

Soluble in water (<1 mg/ml at 25° C), DMSO (33 mg/ml at 25° C), ethanol (15 mg/ml at 25° C), chloroform (1:0.8), and methanol.

저장 :

Store at room temperature

녹는점 :

214-216° C

비등점 :

507.07° C

밀도 :

1.15 g/cm³

굴절률 :

n²⁰_D 1.55

광학 활동 :

α20_D +11±2, c = 2 in chloroform; α24_D +5 in chloroform

IC50 :

Progesterone receptor: IC₅₀ = 11 nM (bovine); GR: IC₅₀ = 19 nM (human); Androgen Receptor: IC₅₀ = 30 nM (rat); CYP2C9: IC₅₀ = 10 µM (human); HegG2: IC₅₀ = 260 µM

Ki 데이타 :

Progesterone receptor: K_i= 1.44 nM (bovine); GR: K_i= 8.77 nM (human); Androgen Receptor: K_i= 20 nM (rat)

WGK 독일 :

3

RTECS :

TU4075000

PubChem CID :

Merck 색인 :

14: 5805

MDL 번호 :

MFCD00056470

EC 번호 :

209-864-5

Beilstein 기재 :

1917291

SMILES :

CC1=C[C@@H]2[C@H](CC[C@]3([C@H]2CC[C@@]3(C(=O)C)OC(=O)C)C)[C@@]4(C1=CC(=O)CC4)C