MCI-186 CAS: 89-25-8
MF: C10H10N2O
MW: 174.20
A free radical scavenger that enhances NGF protein levels via the JNK pathway.

MCI-186 (CAS 89-25-8)

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Synonym: 3-Methyl-1-phenyl-2-pyrazolin-5-one; Edaravone; NSC 2629
Application A free radical scavenger that enhances NGF protein levels via the JNK pathway
CAS 등록번호: 89-25-8
순도: ≥98%
분자량: 174.20
분자식: C10H10N2O
* 참조분석증명서대량의 측정 데이터(함수량포함).
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MCI-186, also known as 3-methyl-1-phenyl-2-pyrazolin-5-one, is a free radical scavenger that has been shown to contain protective properties towards murine brain ischemia. In vitro this compound has been reported to decrease cell death in murine models. Mechanistic studies suggest that MCI-186 enhances neuronal growth factor (NGF) protein levels which are essential for neuronal growth and survival. Furthermore, the enhancement of NGF expression in astrocytes has been thought to be done via the c-Jun N-terminal Kinase (JNK) pathway.


References

1. Kawai, H., et al. 1997. J. Pharmacol. Exp. Ther. 281: 921-927. PMID: 9152402
2. Zhou, F., et al. 2009. Brain Inj. 23: 353-357. PMID: 19330597
3. Lee, B.J., et al. 2010. Brain Res. 1307: 22-27. PMID: 19840779
4. Yoshida, H., et al. 2010. Neurosci. Res. 66: 284-289. PMID: 19954754

Physical State :
Solid
용해도 :
Soluble in water (3.3 g/L) at 20° C, DMSO (~30 mg/ml), methanol, ethanol (~15 mg/ml), DMF (~50 mg/ml), and a 1:9 solution of DMF:PBS(pH7.2) (~0.1 mg/ml).
저장 :
Store at room temperature
녹는점 :
126-128° C (lit.)
비등점 :
287° C at 265 mmHg
밀도 :
1.12 g/cm3 at 20° C
굴절률 :
n20D 1.61
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
WGK Germany :
1
RTECS :
UQ9625000
PubChem CID :
4021
Merck Index :
14: 6713
MDL Number :
MFCD00003138
EC Number :
201-891-0
Beilstein Registry :
609575
SMILES :
CC1=NN(C(=O)C1)C2=CC=CC=C2

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분석증명서

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MCI-186  논문정보

다른 사용자의 MCI-186사용법보기. 클릭하여 PubMed entry보기 .

Citations 1 to 6 of {3} total

PMID: # 26886752  Jangra, A. et al. 2016. Cell. Mol. Neurobiol.

PMID: # 19570630  Sano, H. et al. 2010. Auris Nasus Larynx. 37: 42-46.

PMID: # 19590930  Itoh, T. et al. 2009. Neurotox Res. 16: 378-389.

PMID: # 19666924  Maeno, T. et al. 2009. Br J Ophthalmol. 93: 1479-1482.

PMID: # 19645061  Iida, H. et al. 2009. Muscle Nerve. 40: 582-588.

PMID: # 14666020  Takahashi, G. et al. 2003. J. Thorac. Cardiovasc. Surg. 126: 1461-1466.

Citations 1 to 6 of {3} total
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