MAG Antibody (D-7): sc-376145

MAG Antibody (D-7) is a mouse monoclonal IgG2b antibody that detects myelin-associated glycoprotein (MAG) in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). MAG is a crucial cell-surface adhesion protein in the nervous system, primarily located on the surface of myelinating glial cells, where MAG plays a vital role in linking these cells to neuronal axons. This interaction is essential for the maintenance of myelin integrity and the overall health of the nervous system. MAG (D-7) antibody helps researchers study how MAG on the surface of myelinating cells facilitates myelin sheath formation and contributes to the inhibitory environment regulating axonal growth. Understanding MAG localization and function is important, as MAG inhibitory properties can impact neuronal regeneration and repair processes following injury. Furthermore, growth inhibition mediated by MAG can be counteracted by neurotrophins such as brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF), suggesting a complex interplay between signaling pathways that modulate neuronal responses to myelin-associated cues. Anti-MAG antibody (D-7) is an invaluable tool for researchers investigating MAG roles in neurobiology and implications in neurodegenerative diseases.

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MAG Antibody (D-7) References:

1. Distribution of P0 protein and the myelin-associated glycoprotein in peripheral nerves from Trembler mice.  |  Heath, JW., et al. 1991. J Neurocytol. 20: 439-49. PMID: 1714491
2. Axonal protective effects of the myelin-associated glycoprotein.  |  Nguyen, T., et al. 2009. J Neurosci. 29: 630-7. PMID: 19158290
3. Myelin-associated glycoprotein inhibits the neuronal differentiation of neural progenitors.  |  Li, X., et al. 2009. Neuroreport. 20: 708-12. PMID: 19349915
4. Myelin-associated glycoprotein mediates membrane fusion and entry of neurotropic herpesviruses.  |  Suenaga, T., et al. 2010. Proc Natl Acad Sci U S A. 107: 866-71. PMID: 20080767
5. High affinity sialoside ligands of myelin associated glycoprotein.  |  Zeng, Y., et al. 2011. Bioorg Med Chem Lett. 21: 5045-9. PMID: 21561770
6. Loss of myelin-associated glycoprotein in kearns-sayre syndrome.  |  Lax, NZ., et al. 2012. Arch Neurol. 69: 490-9. PMID: 22491194
7. Developmental and pathophysiological aspects of the myelin-associated glycoprotein.  |  Brady, RO. and Quarles, RH. 1988. Cell Mol Neurobiol. 8: 139-48. PMID: 2457442
8. Nerve ultrasound findings in neuropathy associated with anti-myelin-associated glycoprotein antibodies.  |  Lucchetta, M., et al. 2015. Eur J Neurol. 22: 193-202. PMID: 25174585
9. Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growth.  |  McKerracher, L., et al. 1994. Neuron. 13: 805-11. PMID: 7524558
10. Neuropathy associated with 'benign' anti-myelin-associated glycoprotein IgM gammopathy: clinical, immunological, neurophysiological pathological findings and response to treatment in 33 cases.  |  Ellie, E., et al. 1996. J Neurol. 243: 34-43. PMID: 8869385

The preferred MAG antibody is MAG Antibody (A-11): sc-166849.