KLC1 Antibody (H-7): sc-515792

KLC1 Antibody (H-7) is a mouse monoclonal IgG2b antibody that detects KLC1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). KLC1, or kinesin light chain 1, plays a crucial role in intracellular transport by binding to various cargoes, including organelles and protein complexes, facilitating their movement along microtubules. This transport is vital for maintaining cellular organization and function, particularly in neurons where the transport of synaptic vesicles and other essential components is critical for neurotransmission. KLC1 interacts with kinesin heavy chains to form the functional kinesin motor complex, and proper functioning is essential for neuronal health and signaling. Dysregulation of KLC1 or its interactions can lead to various neurodegenerative diseases, highlighting the importance of studying this protein in both basic and clinical research. Anti-KLC1 antibody (H-7) provides a reliable tool for researchers investigating the dynamics of intracellular transport and the role of kinesin in cellular processes.

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KLC1 Antibody (H-7) References:

1. Control of insulin granule dynamics by AMPK dependent KLC1 phosphorylation.  |  McDonald, A., et al. 2009. Islets. 1: 198-209. PMID: 21099273
2. KLC1-ALK: a novel fusion in lung cancer identified using a formalin-fixed paraffin-embedded tissue only.  |  Togashi, Y., et al. 2012. PLoS One. 7: e31323. PMID: 22347464
3. Microtubule motors transport phagosomes in the RPE, and lack of KLC1 leads to AMD-like pathogenesis.  |  Jiang, M., et al. 2015. J Cell Biol. 210: 595-611. PMID: 26261180
4. Phosphorylation of KLC1 modifies interaction with JIP1 and abolishes the enhanced fast velocity of APP transport by kinesin-1.  |  Chiba, K., et al. 2017. Mol Biol Cell. 28: 3857-3869. PMID: 29093025
5. Characterization of the binding mode of JNK-interacting protein 1 (JIP1) to kinesin-light chain 1 (KLC1).  |  Nguyen, TQ., et al. 2018. J Biol Chem. 293: 13946-13960. PMID: 30026235
6. A Case of Primary Pulmonary Combined Small Cell Carcinoma With Adenocarcinoma Harboring the Same KLC1-ALK Fusion in Both Histologic Components.  |  Bai, Q., et al. 2018. J Thorac Oncol. 13: e197-e199. PMID: 30244852
7. DOC2B promotes insulin sensitivity in mice via a novel KLC1-dependent mechanism in skeletal muscle.  |  Zhang, J., et al. 2019. Diabetologia. 62: 845-859. PMID: 30707251
8. A role for kinesin-1 subunits KIF5B/KLC1 in regulating epithelial mesenchymal plasticity in breast tumorigenesis.  |  Moamer, A., et al. 2019. EBioMedicine. 45: 92-107. PMID: 31204277
9. Chronic intermittent hypoxia aggravates skeletal muscle aging by down-regulating Klc1/grx1 expression via Wnt/β-catenin pathway.  |  Guo, H., et al. 2021. Arch Gerontol Geriatr. 96: 104460. PMID: 34218156
10. Variants in PRKCE and KLC1, Potential Regulators of Type I Psoriasis.  |  Xing, J., et al. 2022. Clin Cosmet Investig Dermatol. 15: 1237-1245. PMID: 35800456

The preferred KLC1 antibody is KLC1 Antibody (L2): sc-58776.