Isotetrandrine CAS: 477-57-6
MF: C38H42N2O6
MW: 622.80
A biscoclaurine alkaloid inhibitor of G protein activation of PLA2.

Isotetrandrine (CAS 477-57-6)

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Synonym: Berbamine methyl ether
Application A biscoclaurine alkaloid inhibitor of G protein activation of PLA2
CAS 등록번호: 477-57-6
순도: 98%
분자량: 622.80
분자식: C38H42N2O6
* 참조분석증명서대량의 측정 데이터(함수량포함).
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Isotetrandrine is a biscoclaurine alkaloid inhibitor of G protein activation of PLA2 but not PLC or PLD. It has been suggested that isotetrandrine suppresses the receptor-mediated phospholipase A2 activation by uncoupling a GTP-binding protein from the enzyme. Isotetrandrine has been reported to inhibit collagen, thrombin, and arachidonic acid-induced platelet aggregation. Isotetrandrine has been found to inhibit arachidonic acid liberation of platelets induced by compound 48/80, antigen, GTPβS and Ca2+. Isotetrandrine is an inhibitor of AR (α1 adrenoceptor).


References

1. Hashizume, T., et al. 1991. Biochem. Pharmacol. 41: 419-423. PMID: 1899790
2. Akiba, S., et al. 1992. Biochem. Pharmacol. 44: 45-50. PMID: 1632837

Physical State :
Solid
용해도 :
Soluble in ethanol (25 mg/ml), DMSO (20 mg/ml), acetone, and chloroform.
저장 :
Store at -20° C
비등점 :
~710.5° C at 760 mmHg (Predicted)
밀도 :
~1.2 g/cm3 (Predicted)
굴절률 :
n20D 1.59
IC50 :
Dopamine transporter: IC50 = 4.2 µM (Rattus norvegicus)
pK Values :
pKb: 7.70
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
RTECS :
NX7285000
PubChem CID :
457825
SMILES :
CN1CCC2=CC(=C3C=C2[[email protected]@H]1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)C[[email protected]@H]6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)OC)OC

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