IL-33 Antibody (Nessy-1): sc-517600

IL-33 Antibody (Nessy-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects IL-33 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-IL-33 antibody (Nessy-1) is available in a non-conjugated form, allowing for versatile experimental use. IL-33, also known as DVS27, IL1F11, C9orf26, or NF-HEV, is a 270 amino acid secreted protein that plays a crucial role in immune response. IL-33 is primarily expressed in tissues such as tonsils and lymph nodes, where IL-33 functions as a cytokine that interacts with the ST2 receptor. This interaction recruits various signaling proteins, including MyD88, IRAK-1, and TRAF6, which are essential for propagating immune signals. IL-33′s ability to induce T helper-associated cytokine activity highlights IL-33′s importance in regulating inflammatory responses and maintaining immune homeostasis. Additionally, IL-33 is involved in the survival and adhesion of mast cells, which are critical for allergic responses and tissue repair, and IL-33 may also play a role in controlling endothelial cell activation, making IL-33 a key player in both innate and adaptive immunity.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

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IL-33 Antibody (Nessy-1) References:

1. The alarmin IL-33 promotes regulatory T-cell function in the intestine.  |  Schiering, C., et al. 2014. Nature. 513: 564-568. PMID: 25043027
2. To promote or inhibit glioma progression, that is the question for IL-33.  |  Robbins, SM. and Senger, DL. 2020. Cell Stress. 5: 19-22. PMID: 33447733
3. IL-33 in Mental Disorders.  |  Pandolfo, G., et al. 2021. Medicina (Kaunas). 57: PMID: 33810498
4. IL-33 in Rheumatic Diseases.  |  Dong, Y., et al. 2021. Front Med (Lausanne). 8: 739489. PMID: 34589505
5. IL1RAP expression and the enrichment of IL-33 activation signatures in severe neutrophilic asthma.  |  Badi, YE., et al. 2023. Allergy. 78: 156-167. PMID: 35986608
6. IL-33 Expression Is Lower in Current Smokers at both Transcriptomic and Protein Levels.  |  Faiz, A., et al. 2023. Am J Respir Crit Care Med. 208: 1075-1087. PMID: 37708400
7. TMED10-mediated unconventional secretion of IL-33 regulates intestinal epithelium differentiation and homeostasis.  |  Wang, Y., et al. 2024. Cell Res. 34: 258-261. PMID: 38185700
8. Macrophages reprogramming improves immunotherapy of IL-33 in peritoneal metastasis of gastric cancer.  |  Che, K., et al. 2024. EMBO Mol Med. 16: 251-266. PMID: 38238529
9. Epithelial overexpression of IL-33 induces eosinophilic esophagitis dependent on IL-13.  |  Masuda, MY., et al. 2024. J Allergy Clin Immunol. 153: 1355-1368. PMID: 38310974
10. IL-33 controls IL-22-dependent antibacterial defense by modulating the microbiota.  |  Röwekamp, I., et al. 2024. Proc Natl Acad Sci U S A. 121: e2310864121. PMID: 38781213

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IL-33 Antibody (Nessy-1) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-IL-33 Antibody (Nessy-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IL-33 Antibody (Nessy-1) Specifications

Alternate Product Name: Interleukin 33

Product Clone Name: Nessy-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 112-270

Epitope Target: IL-33

Epitope Species: human

Product Reactivity/Detection: IL-33

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 50 µg IgG₁ kappa light chain in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for IL-33 Antibody (Nessy-1): N/A

The preferred IL-33 antibody is IL-33 Antibody (4E9): sc-130625.