HPS-1 Antibody (5G12G2): sc-101435
- HPS-1 Antibody (5G12G2) is a mouse monoclonal IgG2a κ HPS-1 antibody provided at 200 µg/ml
- raised against recombinant HPS-1 of human origin
- HPS-1 Antibody (5G12G2) is recommended for detection of HPS-1 of mouse, rat and human origin by WB, IP and ELISA
- Anti-HPS-1 Antibody (5G12G2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for HPS-1 Antibody (5G12G2) for WB applications. These reagents are now offered in bundles with HPS-1 Antibody (5G12G2) (see ordering information below).
HPS-1 Antibody (5G12G2) is a mouse monoclonal IgG2a kappa light chain antibody that detects the HPS-1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). anti-HPS-1 antibody (5G12G2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. HPS-1 plays a crucial role in the biogenesis of lysosome-related organelles, which are essential for proper functioning of various cellular processes, including intracellular protein sorting and maintenance of cellular homeostasis. Defects in HPS-1 can lead to Hermansky-Pudlak syndrome, a rare genetic disorder characterized by oculocutaneous albinism, lysosomal storage defects, and prolonged bleeding due to platelet storage pool deficiency. Understanding HPS-1 function is vital, as HPS-1 is involved in the assembly of protein complexes critical for development and function of cytoplasmic organelles. Using HPS-1 (5G12G2) antibody in research can provide insights into molecular mechanisms underlying Hermansky-Pudlak syndrome and related disorders, ultimately contributing to advancement of therapeutic strategies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HPS-1 Antibody (5G12G2) References:
- Molecular basis of albinism: mutations and polymorphisms of pigmentation genes associated with albinism. | Oetting, WS. and King, RA. 1999. Hum Mutat. 13: 99-115. PMID: 10094567
- The Hermansky-Pudlak syndrome 3 (cocoa) protein is a component of the biogenesis of lysosome-related organelles complex-2 (BLOC-2). | Gautam, R., et al. 2004. J Biol Chem. 279: 12935-42. PMID: 14718540
- Characterization of BLOC-2, a complex containing the Hermansky-Pudlak syndrome proteins HPS3, HPS5 and HPS6. | Di Pietro, SM., et al. 2004. Traffic. 5: 276-83. PMID: 15030569
- Positional cloning of a gene for Hermansky-Pudlak syndrome, a disorder of cytoplasmic organelles. | Oh, J., et al. 1996. Nat Genet. 14: 300-6. PMID: 8896559
- Organization and nucleotide sequence of the human Hermansky-Pudlak syndrome (HPS) gene. | Bailin, T., et al. 1997. J Invest Dermatol. 108: 923-7. PMID: 9182823
- Mutation analysis of patients with Hermansky-Pudlak syndrome: a frameshift hot spot in the HPS gene and apparent locus heterogeneity. | Oh, J., et al. 1998. Am J Hum Genet. 62: 593-8. PMID: 9497254
- Identification of a novel transcript produced by the gene responsible for the Hermansky-Pudlak syndrome in Puerto Rico. | Wildenberg, SC., et al. 1998. J Invest Dermatol. 110: 777-81. PMID: 9579545
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HPS-1 Antibody (5G12G2) | sc-101435 | 200 µg/ml | $322.00 | |||
HPS-1 Antibody (5G12G2): m-IgG Fc BP-HRP Bundle | sc-528723 | 200 µg Ab; 10 µg BP | $361.00 | |||
HPS-1 Antibody (5G12G2): m-IgGκ BP-HRP Bundle | sc-521195 | 200 µg Ab, 40 µg BP | $361.00 | |||
HPS-1 Antibody (5G12G2): m-IgG2a BP-HRP Bundle | sc-547154 | 200 µg Ab; 10 µg BP | $361.00 | |||
HPS-1 Antibody (5G12G2) AC | sc-101435 AC | 500 µg/ml, 25% agarose | $424.00 | |||
HPS-1 Antibody (5G12G2) HRP | sc-101435 HRP | 200 µg/ml | $322.00 | |||
HPS-1 Antibody (5G12G2) FITC | sc-101435 FITC | 200 µg/ml | $336.00 | |||
HPS-1 Antibody (5G12G2) PE | sc-101435 PE | 200 µg/ml | $349.00 | |||
HPS-1 Antibody (5G12G2) Alexa Fluor® 488 | sc-101435 AF488 | 200 µg/ml | $364.00 | |||
HPS-1 Antibody (5G12G2) Alexa Fluor® 546 | sc-101435 AF546 | 200 µg/ml | $364.00 | |||
HPS-1 Antibody (5G12G2) Alexa Fluor® 594 | sc-101435 AF594 | 200 µg/ml | $364.00 | |||
HPS-1 Antibody (5G12G2) Alexa Fluor® 647 | sc-101435 AF647 | 200 µg/ml | $364.00 | |||
HPS-1 Antibody (5G12G2) Alexa Fluor® 680 | sc-101435 AF680 | 200 µg/ml | $364.00 | |||
HPS-1 Antibody (5G12G2) Alexa Fluor® 790 | sc-101435 AF790 | 200 µg/ml | $364.00 |