Date published: 2026-4-23

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Hippuric acid-d5 (CAS 53518-98-2)

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Alternate Names:
N-(Benzoyl-d5)glycine; 2-(Benzoylamino)acetic Acid-d5; 2-Benzamidoacetic Acid-d5
Application:
Hippuric acid-d5 is an isotope labeled compound used for biochemical research
CAS Number:
53518-98-2
Molecular Weight:
184.20
Molecular Formula:
C9H4D5NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Hippuric acid-d5 is a deuterated derivative of hippuric acid. In NMR studies, hippuric acid-d5 provides a simplified pattern of signals by replacing major hydrogen resonance points with deuterium, which have a significantly lower interaction signal. This controlled environment due to deuterium results in a setting where the limited external interference optimizes the underlying options for a more detail-oriented and more easily distinguishable mapping of spectra. Hippuric acid-d5 can be used as a deuterated standard in the laboratory to ensure experimental uniformity and regulation. It is valuable for adjusting and fine-tuning life science radio analysis, where it enhances the control over specific responses of application subsets.


Hippuric acid-d5 (CAS 53518-98-2) References

  1. Normalization strategies for metabonomic analysis of urine samples.  |  Warrack, BM., et al. 2009. J Chromatogr B Analyt Technol Biomed Life Sci. 877: 547-52. PMID: 19185549
  2. Protein-bound uremic toxins in hemodialysis patients measured by liquid chromatography/tandem mass spectrometry and their effects on endothelial ROS production.  |  Itoh, Y., et al. 2012. Anal Bioanal Chem. 403: 1841-50. PMID: 22447217
  3. Metabolomic profiling of anionic metabolites in head and neck cancer cells by capillary ion chromatography with Orbitrap mass spectrometry.  |  Wang, J., et al. 2014. Anal Chem. 86: 5116-24. PMID: 24766394
  4. A liquid chromatography - tandem mass spectrometry method to measure a selected panel of uremic retention solutes derived from endogenous and colonic microbial metabolism.  |  de Loor, H., et al. 2016. Anal Chim Acta. 936: 149-56. PMID: 27566350
  5. Method development and validation for simultaneous quantitation of endogenous hippuric acid and phenylacetylglycine in rat urine using liquid chromatography coupled with electrospray ionization tandem mass spectrometry.  |  Kamiguchi, H., et al. 2016. J Chromatogr B Analyt Technol Biomed Life Sci. 1035: 76-83. PMID: 27697729
  6. Biomarker discovery for drug-induced phospholipidosis: phenylacetylglycine to hippuric acid ratio in urine and plasma as potential markers.  |  Kamiguchi, H., et al. 2017. Biomarkers. 22: 178-188. PMID: 27775443
  7. Analytes related to erythrocyte metabolism are reliable biomarkers for preanalytical error due to delayed plasma processing in metabolomics studies.  |  Jain, M., et al. 2017. Clin Chim Acta. 466: 105-111. PMID: 28069401
  8. Diurnal and Long-term Variation in Plasma Concentrations and Renal Clearances of Circulating Markers of Kidney Proximal Tubular Secretion.  |  Rivara, MB., et al. 2017. Clin Chem. 63: 915-923. PMID: 28188231
  9. Targeted Metabolomics Analysis Identifies Intestinal Microbiota-Derived Urinary Biomarkers of Colonization Resistance in Antibiotic-Treated Mice.  |  Obrenovich, ME., et al. 2017. Antimicrob Agents Chemother. 61: PMID: 28584146
  10. Strategy for Nontargeted Metabolomic Annotation and Quantitation Using a High-Resolution Spectral-Stitching Nanoelectrospray Direct-Infusion Mass Spectrometry with Data-Independent Acquisition.  |  Wang, L., et al. 2021. Anal Chem. 93: 10528-10537. PMID: 34293854
  11. Plasmatic Hippuric Acid as a Hallmark of Frailty in an Italian Cohort: The Mediation Effect of Fruit-Vegetable Intake.  |  Brunelli, L., et al. 2021. J Gerontol A Biol Sci Med Sci. 76: 2081-2089. PMID: 34436596
  12. Comparison of chemometric strategies for potential exposure marker discovery and false-positive reduction in untargeted metabolomics: application to the serum analysis by LC-HRMS after intake of Vaccinium fruit supplements.  |  Renai, L., et al. 2022. Anal Bioanal Chem. 414: 1841-1855. PMID: 35028688
  13. Disruption of the Gut Microbiota Confers Cisplatin Resistance in Epithelial Ovarian Cancer.  |  Chambers, LM., et al. 2022. Cancer Res. 82: 4654-4669. PMID: 36206317

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Hippuric acid-d5, 10 mg

sc-490158
10 mg
$270.00

Hippuric acid-d5, 100 mg

sc-490158A
100 mg
$1811.00