HC Toxin CAS: 83209-65-8
MF: C21H32N4O6
MW: 436.5
An HDAC inhibitor.

HC Toxin (CAS 83209-65-8)

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Synonym: Cyclo[D-Pro-L-Ala-D-Ala-2-(6-oxo-6-oxiranylhexyl)-L-Gly-]
Application An HDAC inhibitor
CAS 등록번호: 83209-65-8
분자량: 436.5
분자식: C21H32N4O6
* 참조분석증명서대량의 측정 데이터(함수량포함).
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HC Toxin is a potent, cell-permeable HDAC (histone deacetylase) inhibitor. HC Toxin inhibits HDACs in maize, Physarum and chicken. HC Toxin has displayed antiprotozoal and antineoplastic activity. HC toxin has induced the expression of the gamma-globin gene in erythroid cells. Antiproliferative activity against T47D human breast cancer cells and cultured mastocytoma cells has been observed with HC toxin treatment.


References

1. Walton, J D., et al., 1985. Reciprocal biological activities of the cyclic tetrapeptides chlamydocin and HC-toxin. Experientia. 41(3): 348-50. PMID: 3918884
2. Brosch, G., et al., 1995. Inhibition of maize histone deacetylases by HC toxin, the host-selective toxin of Cochliobolus carbonum. The Plant cell. 7(11): 1941-50. PMID: 8535144
3. Ross, J., et al., 1996. Comments on the article "Persistent confusion of total entropy and chemical system entropy in chemical thermodynamics" [(1996) Proc. Natl. Acad. Sci. USA 93, 7452-7453]. Proceedings of the National Academy of Sciences of the United States of America. 93(25): 14314; discussion 14315. PMID: 8962046
4. McCaffrey, P G., et al., 1997. Induction of gamma-globin by histone deacetylase inhibitors. Blood. 90(5): 2075-83. PMID: 9292546
5. Joung, Ki Eun., et al., 2004. Antiproliferative effect of trichostatin A and HC-toxin in T47D human breast cancer cells. Archives of pharmacal research. 27(6): 640-5. PMID: 15283467
6. Walton, Jonathan D., et al., 2006. HC-toxin. Phytochemistry. 67(14): 1406-13. PMID: 16839576

Physical State :
Solid
에서 유래된 :
Helminthosporium carbonium
용해도 :
Soluble in DMSO.
저장 :
Store at -20° C
비등점 :
819.18° C at 760 mmHg (Predicted)
밀도 :
1.29 g/cm3 (Predicted)
굴절률 :
n20D 1.56 (Predicted)
IC50 :
E. tenella HDAC: IC50 = 30 nM; Histone deacetylase 11: IC50 = 430 nM (human)
pK Values :
pKa: 13.33
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
WGK Germany :
3
PubChem CID :
23724535
MDL Number :
MFCD00133388
SMILES :
CC1C(=O)NC(C(=O)N2CCCC2C(=O)NC(C(=O)N1)C)CCCCCC(=O)C3CO3

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HC Toxin  논문정보

다른 사용자의 HC Toxin사용법보기. 클릭하여 PubMed entry보기 .

Citations 1 to 1 of {3} total

PMID: # 24227836  Shin, HJ. et al. 2014. J. Virol. 88: 1281-92.

Citations 1 to 1 of {3} total
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