Date published: 2025-9-8
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GSDMDC1 Antibody (64-Y) - Western Blotting - Image 33516
GSDMDC1 항체 (64-Y): sc-81868. 유르캇 전체 세포 용해물에서 GSDMDC1 발현의 웨스턴 블롯 분석.
GSDMDC1 항체 (64-Y): sc-81868. 유르캇 전체 세포 용해물에서 GSDMDC1 발현의 웨스턴 블롯 분석.

GSDMDC1 항체 (64-Y): sc-81868

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데이터 시트
  • GSDMDC1 항체 64-Y 는 마우스 monoclonal IgG1 κ GSDMDC1 항체, 53간행물에 인용, 이며 100 µg/ml으로 제공합니다.
  • human origin의 GSDMDC1의 전체인 1-485 아미노산을 항원으로 사용하였습니다.
  • WB, IP, IF, IHC(P) 와ELISA으로 human origin의 GSDMDC1을 검출할것을 권장합니다.
  • GSDMDC1 (64-Y): sc-81868의 무료10 µg 샘플을 신청하려면 기술지원팀 (또는 로컬 디스트리뷰터)에 연락주세요.
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRP 와 m-IgGκ BP-HRP 는 GSDMDC1 항체 (64-Y) 가 WB and IHC(P) 에 응용될 때 우선으로 사용하는 이차 항체 검사 시약입니다.이 시약은GSDMDC1 항체(64-Y) 와 세트로 제공드립니다. (아래의 주문 정보를 참고해 주시길 바랍니다).

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gasdermin 항체

GSDMDC1 항체 (64-Y)는 인간 유래의 GSDMDC1 단백질을 WB, IP, IF, IHC(P) 및 ELISA로 검출하는 IgG1 κ 마우스 단일 클론 GSDMDC1 항체입니다. GSDMDC1 항체(64-Y)는 비접합 항-GSDMDC1 항체로 제공됩니다. 484개 아미노산 단백질 GSDMDC1을 암호화하는 유전자는 약 1억 4600만 개의 염기로 구성되어 약 800개의 유전자를 암호화하는 인간 염색체 8번에 매핑됩니다. 일부 백혈병과 림프종에서 c-Myc 유전자의 증폭과 함께 8번 염색체 일부의 전위가 발견되며, 일반적으로 예후가 좋지 않은 것과 관련이 있습니다. 8번 염색체의 일부는 정신분열증 및 양극성 장애와 관련이 있는 것으로 알려져 있습니다. 와르카니 증후군 2라고도 알려진 8번 삼염색체는 대부분 조기 유산을 초래하지만, 간혹 생존한 환자에서 모자이크 형태로 나타나 정신 및 운동 발달 지체, 특정 안면 및 발달 결함 등 다양한 증상으로 고통받는 경우도 있습니다. WRN은 8번 염색체에 의해 암호화되는 DNA 헬리카인으로, 초기 노화 장애인 베르너 증후군 환자에게 결함이 있는 것으로 나타났습니다. 8번 염색체는 파이퍼 증후군, 선천성 갑상선 기능 저하증, 와덴버그 증후군과도 관련이 있습니다.

연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.

Alexa Fluor®는 미국 오리건주 Molecular Probes Inc.의 상표입니다.

LI-COR®와 Odyssey®는 LI-COR Biosciences의 등록 상표입니다.

GSDMDC1 항체 (64-Y) 참고문헌:

  1. 염색체 8번과 10번 워크샵.  |  Wildenauer, DB. and Schwab, SG. 1999. Am J Med Genet. 88: 239-43. PMID: 10374738
  2. 정상 염색체 8번이 도입된 베르너 증후군 세포주에서 온전한 WRN 유전자를 우선적으로 발현합니다.  |  Kashino, G., et al. 2001. Biochem Biophys Res Commun. 289: 111-5. PMID: 11708785
  3. II 형 와덴버그 증후군에 대한 새로운 유전자좌의 세포유전학적 매핑.  |  Selicorni, A., et al. 2002. Hum Genet. 110: 64-7. PMID: 11810298
  4. 양극성 장애에 대한 11개의 연관성 연구를 종합적으로 분석한 결과, 염색체 6q와 8q의 감수성 유전자에 대한 강력한 증거가 발견되었습니다.  |  McQueen, MB., et al. 2005. Am J Hum Genet. 77: 582-95. PMID: 16175504
  5. 인간 염색체 8번의 DNA 서열 및 분석.  |  Nusbaum, C., et al. 2006. Nature. 439: 331-5. PMID: 16421571
  6. 인간 암에서 조기 노화 베르너 증후군 유전자의 후성유전학적 비활성화.  |  Agrelo, R., et al. 2006. Proc Natl Acad Sci U S A. 103: 8822-7. PMID: 16723399
  7. 버킷 유사 세포가 있는 비호지킨 림프종은 c-Myc 증폭과 예후가 좋지 않은 것과 관련이 있습니다.  |  Mossafa, H., et al. 2006. Leuk Lymphoma. 47: 1885-93. PMID: 17065002

주문정보

제품명카탈로그 번호 단위가격수량관심품목

GSDMDC1 항체 (64-Y)

sc-81868
100 µg/ml
$316.00

GSDMDC1 (64-Y): m-IgG Fc BP-HRP 번들

sc-537263
100 µg Ab; 10 µg BP
$354.00

GSDMDC1 (64-Y): m-IgGκ BP-HRP 번들

sc-534492
100 µg Ab; 40 µg BP
$354.00

GSDMDC1 (64-Y): m-IgG1 BP-HRP 번들

sc-545115
100 µg Ab; 20 µg BP
$354.00

Hello, I am curious about the specificity of this antibody. In my research it is important that the antibody is specific to the active form of GSDMD (aka GSDMD-N or GSDMD N terminal) and I'm wondering if this product is suitable for my work.

Asked by: Libby
Thank you for your question. For assistance please contact Technical Service. Please call 800-457-3801 or email scbt@scbt.com.
Answered by: BlakeJ
Date published: 2025-07-17

Hello, I am curious about the specificity of this antibody. In my research it is important that the antibody is specific to the active form of GSDMD (aka GSDMD-N or GSDMD N terminal) and I'm wondering if this product is suitable for my work.

Asked by: Libby
Thank you for your question. For assistance please contact Technical Service. Please call 800-457-3801 or email scbt@scbt.com.
Answered by: BlakeJ
Date published: 2025-07-17

Hello, I am curious about the specificity of this antibody. In my research it is important that the antibody is specific to the active form of GSDMD (aka GSDMD-N or GSDMD N terminal) and I'm wondering if this product is suitable for my work.

Asked by: Libby
Thank you for your question. For assistance please contact Technical Service. Please call 800-457-3801 or email scbt@scbt.com.
Answered by: BlakeJ
Date published: 2025-07-17

Blocking should be done either in 5%BSA or 5%non-fat milk.please suggest

Asked by: ras21
Thank you for your question. This antibody has been established with UltraCruz® Blocking Reagent: sc-516214. The optimal blocking reagent is also dependent on the type of sample that is being analyzed. If you encounter unspecific signals, you should use a buffer based on milk-powder or switch to a BSA buffer if your signals are too weak and being overblocked.
Answered by: Tech Support Europe
Date published: 2021-02-09

Does this antibody recognize the cleaved band?

Asked by: ZAQ1
Thank you for your question. This mouse monoclonal antibody was raised against full length recombinant protein of human origin, and the exact epitope recognized has not been determined. We have not conducted any experiments to confirm whether or not the antibody can detect specifically any cleaved or N-terminal fragment of the protein. We would recommend you consult the product citations to see how others are publishing using this antibody.
Answered by: Technical Support
Date published: 2021-01-27

if the antibody will detect the gasdeminD N-terminal fragment?

Asked by: Tang tang
Thank you for your question. This mouse monoclonal antibody was raised against full length recombinant protein of human origin, and the exact epitope recognized has not been determined. We have not conducted any experiments to confirm whether or not the antibody can detect specifically any cleaved or N-terminal fragment of the protein. We would recommend you consult the product citations to see how others are publishing using this antibody.
Answered by: Technical Support
Date published: 2023-07-04

I have the same question as Tang Tang : Does the GSDMDC1 Antibody (64-Y): sc-81868 detect the human gasdemin D N-terminal fragment ?? Thank you.

Asked by: MariL
Thank you for your question. This mouse monoclonal antibody was raised against full length recombinant protein of human origin, and the exact epitope recognized has not been determined. We have not conducted any experiments to confirm whether or not the antibody can detect specifically any cleaved or N-terminal fragment of the protein. We would recommend you consult the product citations to see how others are publishing using this antibody.
Answered by: Technical Support
Date published: 2019-01-14

I would like to ask abput free sample of GSDMD antibody.

Asked by: MartaZ
Thank you for your question. If you have an interest in testing a free 10 µg sample of GSDMDC1 (64-Y): sc-81868 please contact our Technical Service by phone or email or by Live Chat.
Answered by: SCBT Heidelberg Support
Date published: 2018-11-26
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Rated 5 out of 5 by from its effect is goodwhen i was master, i used it to do some experiments,and my work get the nod of my teacher. and I graduated and published a good article
Date published: 2023-03-13
Rated 4 out of 5 by from WORKS!!Thx for the sample, it's works in THP-1 lysate and SN, but i really want its can get the P30 signal in WB..
Date published: 2017-12-27
Rated 3 out of 5 by from It is a good antibodyThanks for the free 10 µg sample from the company, but in my study and my vascular endothelial cell, the dilution 1:500 was used, the graph is not good, I need more study.
Date published: 2017-09-21
Rated 3 out of 5 by from Works... but low specificity for a mAbI'm sure that this antibody is good for validating transfections or something along those lines (though one could just tag a transfected protein)... for cells (e.g. THP1 monocytes) that don't seem to express as much GSDMD, this antibody has pretty high background in my hands. Though the strongest band is 52 kDa, there are lots of other bands of lesser but still quite visible intensity (these do not correspond to caspase-cleaved GSDMD, either). Picture attached to show what I mean.
Date published: 2017-07-14
Rated 5 out of 5 by from good for WB and IFI used this antibody for immunofluorescence (1:300) and WB(1:800), and I got very good and clean results for both application.
Date published: 2017-05-24
Rated 4 out of 5 by from Great Ab!Works well for western blotting on THP1 cell lysates.
Date published: 2017-03-29
Rated 5 out of 5 by from great GSDMDC1 detectionWorks well with paraffin-embedded sections for IHC. Great for human GSDMDC1 detection.
Date published: 2017-01-12
Rated 5 out of 5 by from tumor samplesWorked well for western blot with tumor samples,Good signal in western blot using 1:1000.
Date published: 2016-12-17
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GSDMDC1 항체 (64-Y) is rated 4.2 out of 5 by 12.
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