GLP-2 Antibody (11E5): sc-80570

GLP-2 Antibody (11E5) is a mouse monoclonal IgG1 antibody that detects Glucagon-like peptide-2 (GLP-2) in human samples through enzyme-linked immunosorbent assay (ELISA). GLP-2 is a crucial peptide hormone primarily produced in the intestines, where GLP-2 plays a significant role in promoting intestinal epithelial growth and enhancing nutrient absorption. This function is vital for maintaining gut health and integrity, particularly after injury or during conditions that compromise the intestinal barrier. By stimulating the proliferation of intestinal epithelial cells, GLP-2 contributes to the repair and regeneration of the gut lining, which is essential for proper digestion and nutrient uptake. Additionally, GLP-2 has been implicated in various physiological processes, including the regulation of gut motility and the modulation of insulin secretion, making GLP-2 a key player in metabolic homeostasis. Anti-GLP-2 antibody (11E5) is an invaluable tool for researchers studying gastrointestinal health, metabolic disorders, and the intricate signaling pathways involving this important hormone.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

GLP-2 Antibody (11E5) References:

1. GLP-2 Analogues as First Specific Treatment of Intestinal Failure.  |  Blumenstein, I. 2019. Visc Med. 35: 320-323. PMID: 31768396
2. SERUM GLP-2 is Increased in Association with Excess Gestational Weight Gain.  |  Kahr, MK., et al. 2023. Am J Perinatol. 40: 400-406. PMID: 33940644
3. Glucagon-like peptide 2 (GLP-2) in bovine colostrum and transition milk.  |  Inabu, Y., et al. 2021. Heliyon. 7: e07046. PMID: 34041395
4. [Gly²]-GLP-2, But Not Glucagon or [D-Ala²]-GLP-1, Controls Collagen Crosslinking in Murine Osteoblast Cultures.  |  Mieczkowska, A., et al. 2021. Front Endocrinol (Lausanne). 12: 721506. PMID: 34421828
5. The dual GLP-1 and GLP-2 receptor agonist dapiglutide promotes barrier function in murine short bowel.  |  Reiner, J., et al. 2022. Ann N Y Acad Sci. 1514: 132-141. PMID: 35580981
6. Therapeutic Potential of GLP-2 Analogs in Gastrointestinal Disorders: Current Knowledge, Nutritional Aspects, and Future Perspectives.  |  Kounatidis, D., et al. 2022. Curr Nutr Rep. 11: 618-642. PMID: 35933503
7. Differential Responses of the GLP-1 and GLP-2 Receptors to N-Terminal Modification of a Dual Agonist.  |  Gibadullin, R., et al. 2023. J Am Chem Soc. 145: 12105-12114. PMID: 37235770
8. A specific gut microbiota signature is associated with an enhanced GLP-1 and GLP-2 secretion and improved metabolic control in patients with type 2 diabetes after metabolic Roux-en-Y gastric bypass.  |  Hernández-Montoliu, L., et al. 2023. Front Endocrinol (Lausanne). 14: 1181744. PMID: 37916149
9. Effects of Exogenous GIP and GLP-2 on Bone Turnover in Individuals With Type 2 Diabetes.  |  Skov-Jeppesen, K., et al. 2024. J Clin Endocrinol Metab. 109: 1773-1780. PMID: 38217866
10. GLP-2 ameliorates D-galactose induced muscle aging by IGF-1/Pi3k/Akt/FoxO3a signaling pathway in C2C12 cells and mice.  |  Ye, YL., et al. 2024. Arch Gerontol Geriatr. 124: 105462. PMID: 38692155

The preferred Glucagon antibody is Glucagon Antibody (K79bB10): sc-57171.