Frabin Antibody (43): sc-136333
- Frabin Antibody (43) is a mouse monoclonal IgG1 κ Frabin antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 91-192 of Frabin of rat origin
- recommended for detection of Frabin of mouse, rat and human origin by WB, IP and IF
- available conjugated to agarose for IP; and to HRP for WB, IHC(P) and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Frabin Antibody (43) for WB applications. These reagents are now offered in bundles with Frabin Antibody (43) (see ordering information below).
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Frabin Antibody (43) is a mouse monoclonal IgG1 kappa light chain antibody that detects Frabin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-Frabin antibody (43) is available in both non-conjugated and various conjugated forms, including agarose and horseradish peroxidase (HRP). Frabin, also known as FGD1-related F-actin binding protein, plays a crucial role in cellular dynamics by acting as a guanine nucleotide exchange factor (GEF) for the Rho family member CDC42, which is essential for regulating cytoskeletal organization and cell signaling. The interaction between Frabin and CDC42 facilitates CDC42 activation, allowing CDC42 to toggle between active GTP-bound state and inactive GDP-bound state, thereby influencing processes such as cell growth, migration, and morphology. Frabin′s ability to bind actin filaments suggests a vital link between CDC42 signaling and the cytoskeleton, highlighting Frabin′s significance in maintaining cellular architecture and function.
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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.
Download thiomersal SDS
Frabin Antibody (43) References:
- The GTPase superfamily: a conserved switch for diverse cell functions. | Bourne, HR., et al. 1990. Nature. 348: 125-32. PMID: 2122258
- Proteins regulating Ras and its relatives. | Boguski, MS. and McCormick, F. 1993. Nature. 366: 643-54. PMID: 8259209
- The Dbl family of oncogenes. | Cerione, RA. and Zheng, Y. 1996. Curr Opin Cell Biol. 8: 216-22. PMID: 8791419
- Dbl family proteins. | Whitehead, IP., et al. 1997. Biochim Biophys Acta. 1332: F1-23. PMID: 9061011
- Frabin, a novel FGD1-related actin filament-binding protein capable of changing cell shape and activating c-Jun N-terminal kinase. | Obaishi, H., et al. 1998. J Biol Chem. 273: 18697-700. PMID: 9668039
- CDC42 and FGD1 cause distinct signaling and transforming activities. | Whitehead, IP., et al. 1998. Mol Cell Biol. 18: 4689-97. PMID: 9671479
- Rho family proteins and Ras transformation: the RHOad less traveled gets congested. | Zohn, IM., et al. 1998. Oncogene. 17: 1415-38. PMID: 9779988
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Frabin Antibody (43) | sc-136333 | 200 µg/ml | $322.00 | |||
Frabin Antibody (43): m-IgG Fc BP-HRP Bundle | sc-528812 | 200 µg Ab; 10 µg BP | $361.00 | |||
Frabin Antibody (43): m-IgGκ BP-HRP Bundle | sc-521356 | 200 µg Ab, 40 µg BP | $361.00 | |||
Frabin Antibody (43): m-IgG1 BP-HRP Bundle | sc-543143 | 200 µg Ab; 20 µg BP | $361.00 | |||
Frabin Antibody (43) AC | sc-136333 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Frabin Antibody (43) HRP | sc-136333 HRP | 200 µg/ml | $322.00 |