epsin 1 Antibody (G-11): sc-55564

Epsin 1 Antibody (G-11) is a mouse monoclonal IgG1 antibody that detects Epsin 1 in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Epsin 1 plays a crucial role in the endocytic process, particularly in the formation of Clathrin-coated vesicles, which are essential for the internalization of membrane proteins and lipids. Epsin 1′s structure includes an epsin N-terminal homology (ENTH) domain that facilitates membrane binding and a Clathrin-binding motif, which is vital for interaction with Clathrin and other endocytic proteins. This structural configuration allows Epsin 1 to effectively mediate membrane invagination during vesicle formation, a process critical for cellular communication and nutrient uptake. Additionally, Epsin 1′s localization to the leading edge of vesicular coated pits highlights an active role in the dynamic remodeling of the plasma membrane, making Epsin 1 a key player in the regulation of endocytosis. Anti-Epsin 1 antibody (G-11) is an invaluable tool for researchers studying the mechanisms of endocytosis and its implications in various physiological and pathological processes.

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epsin 1 Antibody (G-11) References:

1. Membrane bending by protein-protein crowding.  |  Stachowiak, JC., et al. 2012. Nat Cell Biol. 14: 944-9. PMID: 22902598
2. Elucidation of different inhibition mechanism of small chemicals on PtdInsP-binding domains using in silico docking experiments.  |  Kim, Y. and Yoon, Y. 2014. Bioorg Med Chem Lett. 24: 2256-62. PMID: 24736117
3. Endocytosis of Ubiquitylation-Deficient EGFR Mutants via Clathrin-Coated Pits is Mediated by Ubiquitylation.  |  Fortian, A., et al. 2015. Traffic. 16: 1137-54. PMID: 26251007
4. Membrane remodeling by the M2 amphipathic helix drives influenza virus membrane scission.  |  Martyna, A., et al. 2017. Sci Rep. 7: 44695. PMID: 28317901
5. Endocytic proteins are partitioned at the edge of the clathrin lattice in mammalian cells.  |  Sochacki, KA., et al. 2017. Nat Cell Biol. 19: 352-361. PMID: 28346440
6. Epsins Regulate Mouse Embryonic Stem Cell Exit from Pluripotency and Neural Commitment by Controlling Notch Activation.  |  Cardano, M., et al. 2019. Stem Cells Int. 2019: 4084351. PMID: 30930949
7. Enhancing the activity of membrane remodeling epsin-peptide by trimerization.  |  Hsu, WY., et al. 2020. Bioorg Med Chem Lett. 30: 127190. PMID: 32317210
8. EPSIN1 Contributes to Plant Immunity by Modulating the Abundance of Pattern Recognition Receptors at the Plasma Membrane.  |  Zhang, W. 2020. Plant Physiol. 183: 3-4. PMID: 32385169
9. Protein-Protein Interactions on Membrane Surfaces Analysed Using Pull-Downs with Supported Bilayers on Silica Beads.  |  Andhare, DS., et al. 2022. J Membr Biol. 255: 591-597. PMID: 35226119
10. Intersectin1 promotes clathrin-mediated endocytosis by organizing and stabilizing endocytic protein interaction networks.  |  Jin, M., et al. 2024. Cell Rep. 43: 114989. PMID: 39580802

The preferred epsin 1 antibody is epsin 1 Antibody (C-11): sc-55556.