Ep-CAM Antibody (VU-1D9): sc-51681

Ep-CAM Antibody (VU-1D9) is a mouse monoclonal IgG1 antibody that detects Ep-CAM in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Ep-CAM, also known as tumor-associated calcium signal transducer 1 and MK-1, is a monomeric membrane glycoprotein predominantly expressed in normal human epithelial tissues and various carcinomas. The human Ep-CAM gene encodes a 314 amino acid protein that exists in two forms, with the major form being more prevalent and the minor form being reduced upon treatment with the amino-glycosylation inhibitor tunicamycin. Notably, Ep-CAM plays a crucial role in cell adhesion due to its extracellular domain, which contains two epidermal growth factor-like repeats followed by a cysteine-poor region essential for adhesive properties. This function is particularly important in maintaining tissue integrity and facilitating cellular communication, making Ep-CAM a significant marker for tumor progression and a potential target for therapeutic interventions in solid tumors. Anti-Ep-CAM antibody (VU-1D9) serves as a valuable tool for researchers aiming to explore Ep-CAM′s role in cancer biology and for developing targeted therapies.

The preferred Ep-CAM antibody is Ep-CAM Antibody (C-10): sc-25308.