DUXBL Antibody (E-10): sc-137190
- DUXBL Antibody (E-10) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 116-314 of DUXBL of mouse origin
- DUXBL Antibody (E-10) is recommended for detection of DUXBL of mouse origin by WB, IP, IF and ELISA
- Anti-DUXBL Antibody (E-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for DUXBL Antibody (E-10) for WB applications. These reagents are now offered in bundles with DUXBL Antibody (E-10) (see ordering information below).
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SEE ALSO...
DUXBL Antibody (E-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects DUXBL protein of mouse origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DUXBL (E-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. DUXBL protein is part of the double homeobox (DUX) family, which plays a crucial role in regulating gene expression during early embryonic development. DUXBL is involved in activating genes essential for the transition from a pluripotent state to a more differentiated state, making DUXBL vital for proper cellular development and function. The DUX family, which includes DUX1, DUX2, DUX3, DUX4, and DUX5, is characterized by homeobox domains that facilitate DNA binding and transcriptional regulation. DUX4, also referred to as DUX10, has been implicated in Facioscapulohumeral muscular dystrophy (FSHD) due to its location within the D4Z4 repeat unit, highlighting DUXBL′s importance in both normal development and disease contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
DUXBL Antibody (E-10) References:
- Nucleotide sequence of the partially deleted D4Z4 locus in a patient with FSHD identifies a putative gene within each 3.3 kb element. | Gabriëls, J., et al. 1999. Gene. 236: 25-32. PMID: 10433963
- Active genes in junk DNA? Characterization of DUX genes embedded within 3.3 kb repeated elements. | Beckers, M., et al. 2001. Gene. 264: 51-7. PMID: 11245978
- Intracellular trafficking and dynamics of double homeodomain proteins. | Ostlund, C., et al. 2005. Biochemistry. 44: 2378-84. PMID: 15709750
- Fusion between CIC and DUX4 up-regulates PEA3 family genes in Ewing-like sarcomas with t(4;19)(q35;q13) translocation. | Kawamura-Saito, M., et al. 2006. Hum Mol Genet. 15: 2125-37. PMID: 16717057
- The DUX4 gene at the FSHD1A locus encodes a pro-apoptotic protein. | Kowaljow, V., et al. 2007. Neuromuscul Disord. 17: 611-23. PMID: 17588759
- Evolutionary conservation of a coding function for D4Z4, the tandem DNA repeat mutated in facioscapulohumeral muscular dystrophy. | Clapp, J., et al. 2007. Am J Hum Genet. 81: 264-79. PMID: 17668377
- DUX4, a candidate gene of facioscapulohumeral muscular dystrophy, encodes a transcriptional activator of PITX1. | Dixit, M., et al. 2007. Proc Natl Acad Sci U S A. 104: 18157-62. PMID: 17984056
- Characterization of a double homeodomain protein (DUX1) encoded by a cDNA homologous to 3.3 kb dispersed repeated elements. | Ding, H., et al. 1998. Hum Mol Genet. 7: 1681-94. PMID: 9736770
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DUXBL Antibody (E-10) | sc-137190 | 200 µg/ml | $322.00 | |||
DUXBL Antibody (E-10): m-IgG Fc BP-HRP Bundle | sc-528872 | 200 µg Ab; 10 µg BP | $361.00 | |||
DUXBL Antibody (E-10): m-IgGκ BP-HRP Bundle | sc-521447 | 200 µg Ab, 40 µg BP | $361.00 | |||
DUXBL Antibody (E-10): m-IgG1 BP-HRP Bundle | sc-543182 | 200 µg Ab; 20 µg BP | $361.00 | |||
DUXBL Antibody (E-10) AC | sc-137190 AC | 500 µg/ml, 25% agarose | $424.00 | |||
DUXBL Antibody (E-10) HRP | sc-137190 HRP | 200 µg/ml | $322.00 | |||
DUXBL Antibody (E-10) FITC | sc-137190 FITC | 200 µg/ml | $336.00 | |||
DUXBL Antibody (E-10) PE | sc-137190 PE | 200 µg/ml | $349.00 | |||
DUXBL Antibody (E-10) Alexa Fluor® 488 | sc-137190 AF488 | 200 µg/ml | $364.00 | |||
DUXBL Antibody (E-10) Alexa Fluor® 546 | sc-137190 AF546 | 200 µg/ml | $364.00 | |||
DUXBL Antibody (E-10) Alexa Fluor® 594 | sc-137190 AF594 | 200 µg/ml | $364.00 | |||
DUXBL Antibody (E-10) Alexa Fluor® 647 | sc-137190 AF647 | 200 µg/ml | $364.00 | |||
DUXBL Antibody (E-10) Alexa Fluor® 680 | sc-137190 AF680 | 200 µg/ml | $364.00 | |||
DUXBL Antibody (E-10) Alexa Fluor® 790 | sc-137190 AF790 | 200 µg/ml | $364.00 |