Molecular structure of Decylubiquinone, CAS Number: 55486-00-5
Decylubiquinone (CAS 55486-00-5)
See product citations (10)
Alternate Names:
Decylubiquinone also known as 2,3-Dimethoxy-5-methyl-6-decyl-1,4-benzoquinone; 6-Decylubiquinone; Decyl-ubiquinone
Application:
Decylubiquinone is inhibits the Ca2+-dependent mitochondrial permeability transition pore (MPTP) and also inhibits etoposide-induced apoptosis
CAS Number:
55486-00-5
Purity:
≥97%
Molecular Weight:
322.44
Molecular Formula:
C19H30O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Decylubiquinone inhibits the Ca2+-dependent mitochondrial permeability transition pore (MPTP), with a maximum effect on Ca2+ retention capacity of rat liver mitochondria at 100 μM. It also inhibits etoposide-induced apoptosis in L929 cells at 5 μM. It does not, however, inhibit respiration. Additionally, decylubiquinone blocks reactive oxygen species production in response to glutathione depletion.
Decylubiquinone (CAS 55486-00-5) References
- Electrogenic proton transfer in Rhodobacter sphaeroides reaction centers: effect of coenzyme Q(10) substitution by decylubiquinone in the Q(B) binding site. | Gopta, OA., et al. 2001. FEBS Lett. 499: 116-20. PMID: 11418124
- Mutagenesis of subunit N of the Escherichia coli complex I. Identification of the initiation codon and the sensitivity of mutants to decylubiquinone. | Amarneh, B. and Vik, SB. 2003. Biochemistry. 42: 4800-8. PMID: 12718520
- The Coenzyme Q10 analog decylubiquinone inhibits the redox-activated mitochondrial permeability transition: role of mitcohondrial [correction mitochondrial] complex III. | Armstrong, JS., et al. 2003. J Biol Chem. 278: 49079-84. PMID: 12949071
- Decylubiquinol impedes mitochondrial respiratory chain complex I activity. | Bénit, P., et al. 2008. Mol Cell Biochem. 314: 45-50. PMID: 18414996
- Micelle-supported electroenzymology: Succinate dehydrogenation by escherichia coli fumarate reductase in decylubiquinone and octyl glucoside micelles. | Kinnear, KT. and Monbouquette, HG. 1993. Biotechnol Bioeng. 42: 140-4. PMID: 18609658
- Decylubiquinone increases mitochondrial function in synaptosomes. | Telford, JE., et al. 2010. J Biol Chem. 285: 8639-45. PMID: 20080966
- The effects of idebenone on mitochondrial bioenergetics. | Giorgio, V., et al. 2012. Biochim Biophys Acta. 1817: 363-9. PMID: 22086148
- Characterization of the Type III sulfide:quinone oxidoreductase from Caldivirga maquilingensis and its membrane binding. | Lencina, AM., et al. 2013. Biochim Biophys Acta. 1827: 266-75. PMID: 23103448
- EDL-360: A Potential Novel Antiglioma Agent. | Hosni-Ahmed, A., et al. 2014. J Cancer Sci Ther. 6: 370-377. PMID: 25574358
- Decylubiquinone suppresses breast cancer growth and metastasis by inhibiting angiogenesis via the ROS/p53/ BAI1 signaling pathway. | Cao, J., et al. 2020. Angiogenesis. 23: 325-338. PMID: 32020421
- Decylubiquinone Inhibits Colorectal Cancer Growth Through Upregulating Sirtuin2. | Li, J., et al. 2021. Front Pharmacol. 12: 804265. PMID: 35177983
- Altered brown adipose tissue mitochondrial function in newborn fragile X syndrome mice. | Somnay, YR., et al. 2022. Mitochondrion. 65: 1-10. PMID: 35500860
- Protective role of Decylubiquinone against secondary melanoma at lung in B16F10 induced mice by reducing E-cadherin expression and ameliorating ROCKII-Limk1/2-Cofiliin mediated metastasis. | Chatterjee, S., et al. 2023. Cell Signal. 101: 110486. PMID: 36208704
- Substrates of energy metabolism attenuate methamphetamine-induced neurotoxicity in striatum. | Stephans, SE., et al. 1998. J Neurochem. 71: 613-21. PMID: 9681451
Inhibitor of:
ALG9, Apoptosis, Cyclophilin D, DSCR 5, EOGT_A130022J15Rik, FAM113B, GGtase-α, GGTase-Iα, MPV17, OPA3, PDSS1, PIG-L, PIG-W, PIG-Z, SLC25A14, SLC25A34, SLC25A36, SLC25A44, SPCS2, Thomsen-Friedenreich, VIP36, and ZDHHC6.Activator of:
2900010M23Rik, COQ6, NDUFA12, NDUFS4, QCR10, UCRC, and UQCRHL.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Decylubiquinone, 10 mg | sc-358659 | 10 mg | $70.00 | |||
Decylubiquinone, 50 mg | sc-358659A | 50 mg | $269.00 |