DcR3 Antibody (F-4): sc-365755
- DcR3 Antibody (F-4) is a mouse monoclonal IgG2b κ DcR3 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 279-300 at the C-terminus of DcR3 (decoy receptor 3) of human origin
- DcR3 Antibody (F-4) is recommended for detection of DcR3 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-DcR3 Antibody (F-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGκ BP-HRP is the preferred secondary detection reagent for DcR3 Antibody (F-4) for WB applications. This reagent is now offered in a bundle with DcR3 Antibody (F-4) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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DcR3 Antibody (F-4) is a mouse monoclonal IgG2b kappa light chain antibody that detects DcR3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DcR3 (F-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. DcR3 plays a critical role in modulating immune response by acting as a decoy receptor for tumor necrosis factor (TNF) ligands, particularly in the context of apoptosis. By binding to TNF-related ligands, DcR3 can inhibit the activation of pro-apoptotic signaling pathways, thereby contributing to cellular resistance against apoptosis. This function is particularly important in the tumor microenvironment, where DcR3 may help cancer cells evade immune surveillance and promote tumor growth. Understanding DcR3′s role in these processes can provide insights into potential therapeutic strategies targeting immune evasion in cancer.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
DcR3 Antibody (F-4) References:
- A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis. | Yu, KY., et al. 1999. J Biol Chem. 274: 13733-6. PMID: 10318773
- DcR3 protects THP-1 macrophages from apoptosis by increasing integrin alpha4. | Tateishi, K., et al. 2009. Biochem Biophys Res Commun. 389: 593-8. PMID: 19748482
- The Fas death factor. | Nagata, S. and Golstein, P. 1995. Science. 267: 1449-56. PMID: 7533326
- The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death. | Smith, CA., et al. 1994. Cell. 76: 959-62. PMID: 8137429
- A novel domain within the 55 kd TNF receptor signals cell death. | Tartaglia, LA., et al. 1993. Cell. 74: 845-53. PMID: 8397073
- A death-domain-containing receptor that mediates apoptosis. | Kitson, J., et al. 1996. Nature. 384: 372-5. PMID: 8934525
- The receptor for the cytotoxic ligand TRAIL. | Pan, G., et al. 1997. Science. 276: 111-3. PMID: 9082980
- An antagonist decoy receptor and a death domain-containing receptor for TRAIL. | Pan, G., et al. 1997. Science. 277: 815-8. PMID: 9242610
- Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. | Sheridan, JP., et al. 1997. Science. 277: 818-21. PMID: 9242611
- A novel receptor for Apo2L/TRAIL contains a truncated death domain. | Marsters, SA., et al. 1997. Curr Biol. 7: 1003-6. PMID: 9382840
- TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling. | Pan, G., et al. 1998. FEBS Lett. 424: 41-5. PMID: 9537512
- Identification and functional characterization of DR6, a novel death domain-containing TNF receptor. | Pan, G., et al. 1998. FEBS Lett. 431: 351-6. PMID: 9714541
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DcR3 Antibody (F-4) | sc-365755 | 200 µg/ml | $322.00 | |||
DcR3 Antibody (F-4): m-IgGκ BP-HRP Bundle | sc-552361 | 200 µg Ab; 40 µg BP | $361.00 | |||
DcR3 Antibody (F-4) AC | sc-365755 AC | 500 µg/ml, 25% agarose | $424.00 | |||
DcR3 Antibody (F-4) HRP | sc-365755 HRP | 200 µg/ml | $322.00 | |||
DcR3 Antibody (F-4) FITC | sc-365755 FITC | 200 µg/ml | $336.00 | |||
DcR3 Antibody (F-4) PE | sc-365755 PE | 200 µg/ml | $349.00 | |||
DcR3 Antibody (F-4) Alexa Fluor® 488 | sc-365755 AF488 | 200 µg/ml | $364.00 | |||
DcR3 Antibody (F-4) Alexa Fluor® 546 | sc-365755 AF546 | 200 µg/ml | $364.00 | |||
DcR3 Antibody (F-4) Alexa Fluor® 594 | sc-365755 AF594 | 200 µg/ml | $364.00 | |||
DcR3 Antibody (F-4) Alexa Fluor® 647 | sc-365755 AF647 | 200 µg/ml | $364.00 | |||
DcR3 Antibody (F-4) Alexa Fluor® 680 | sc-365755 AF680 | 200 µg/ml | $364.00 | |||
DcR3 Antibody (F-4) Alexa Fluor® 790 | sc-365755 AF790 | 200 µg/ml | $364.00 | |||
DcR3 (F-4) Neutralizing Peptide | sc-365755 P | 100 µg/0.5 ml | $69.00 |