DCDC2B Antibody (E-6): sc-514743

DCDC2B Antibody (E-6) is a mouse monoclonal IgM antibody that detects DCDC2B protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-DCDC2B antibody (E-6) is available as the non-conjugated form. DCDC2B, or doublecortin domain containing 2B, is a 349 amino acid protein that belongs to the doublecortin family, characterized by two doublecortin domains that facilitate binding to tubulin and promote microtubule polymerization. This function is crucial for neuronal development and stability, as microtubules are essential components of the cytoskeleton that provide structural support and play a key role in intracellular transport. The gene encoding DCDC2B is located on human chromosome 1, which houses approximately 3,000 genes and is associated with various diseases, including certain cancers and genetic disorders. The importance of DCDC2B in neurogenesis and potential implications in neurodevelopmental disorders make DCDC2B a significant target for research. Anti-DCDC2B antibody (E-6) enables valuable insights into DCDC2B′s role in cellular processes and impact on health and disease.

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DCDC2B Antibody (E-6) References:

1. Schizophrenia and affective disorders--cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family.  |  Blackwood, DH., et al. 2001. Am J Hum Genet. 69: 428-33. PMID: 11443544
2. New insights into the evolution of chromosome 1.  |  Weise, A., et al. 2005. Cytogenet Genome Res. 108: 217-22. PMID: 15545733
3. Cell biology: ageing nucleus gets out of shape.  |  Lans, H. and Hoeijmakers, JH. 2006. Nature. 440: 32-4. PMID: 16511477
4. Chromosome 1 abnormalities in multiple myeloma.  |  Marzin, Y., et al. 2006. Anticancer Res. 26: 953-9. PMID: 16619492
5. Genes and schizophrenia: beyond schizophrenia: the role of DISC1 in major mental illness.  |  Hennah, W., et al. 2006. Schizophr Bull. 32: 409-16. PMID: 16699061
6. The DNA sequence and biological annotation of human chromosome 1.  |  Gregory, SG., et al. 2006. Nature. 441: 315-21. PMID: 16710414
7. The evolving doublecortin (DCX) superfamily.  |  Reiner, O., et al. 2006. BMC Genomics. 7: 188. PMID: 16869982
8. Genomic organization of the selectin family of leukocyte adhesion molecules on human and mouse chromosome 1.  |  Watson, ML., et al. 1990. J Exp Med. 172: 263-72. PMID: 1694218
9. The doublecortin gene family and disorders of neuronal structure.  |  Dijkmans, TF., et al. 2010. Cent Nerv Syst Agents Med Chem. 10: 32-46. PMID: 20236041

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-DCDC2B Antibody (E-6) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-DCDC2B Antibody (E-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

DCDC2B Antibody (E-6) Specifications

Alternate Product Name: DCDC2B

Product Clone Name: E-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 55-76

Epitope Target: DCDC2B

Epitope Species: human

Product Reactivity/Detection: DCDC2B

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for DCDC2B Antibody (E-6): P: Blocking Peptide