CIN85 Antibody (C-8): sc-271567
- CIN85 Antibody (C-8) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 566-606 within an internal region of CIN85 of human origin
- recommended for detection of CIN85 of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CIN85 Antibody (C-8) for WB applications. These reagents are now offered in bundles with CIN85 Antibody (C-8) (see ordering information below).
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CIN85 Antibody (C-8) is a mouse monoclonal IgG1 antibody that detects CIN85 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CIN85 is a crucial adaptor protein that plays a significant role in cellular signaling by interacting with various proteins, including receptor tyrosine kinases and endocytic machinery. CIN85′s ability to form multimeric complexes is essential for regulating processes such as T-cell activation and apoptosis in neuronal cells. CIN85′s structure, characterized by three SH3 domains, a proline-rich region, and a coiled-coil domain, is vital for function, as these domains facilitate specific protein-protein interactions necessary for signaling complex assembly. By coordinating these interactions, CIN85 contributes to the downregulation and degradation of receptor tyrosine kinases, thereby influencing critical cellular responses and maintaining homeostasis. Anti-CIN85 antibody (C-8) serves as an invaluable tool for researchers exploring intricate signaling networks involving CIN85.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CIN85 Antibody (C-8) References:
- CIN85 regulates the ability of MEKK4 to activate the p38 MAP kinase pathway. | Aissouni, Y., et al. 2005. Biochem Biophys Res Commun. 338: 808-14. PMID: 16256071
- CIN85 associates with endosomal membrane and binds phosphatidic acid. | Zhang, J., et al. 2009. Cell Res. 19: 733-46. PMID: 19417776
- The adaptor protein Ruk/CIN85 activates plasminogen activator inhibitor-1 (PAI-1) expression via hypoxia-inducible factor-1alpha. | Samoylenko, A., et al. 2010. Thromb Haemost. 103: 901-9. PMID: 20216986
- CIN85 interacting proteins in B cells-specific role for SHIP-1. | Büchse, T., et al. 2011. Mol Cell Proteomics. 10: M110.006239. PMID: 21725061
- Increased levels of the HER1 adaptor protein Rukl/CIN85 contribute to breast cancer malignancy. | Samoylenko, A., et al. 2012. Carcinogenesis. 33: 1976-84. PMID: 22791810
- Adaptor protein complex of FRS2β and CIN85/CD2AP provides a novel mechanism for ErbB2/HER2 protein downregulation. | Minegishi, Y., et al. 2013. Cancer Sci. 104: 345-52. PMID: 23279575
- Inhibition of CIN85-mediated invasion by a novel SH3 domain binding motif in the lysyl oxidase propeptide. | Sato, S., et al. 2013. PLoS One. 8: e77288. PMID: 24167568
- Inhibition of T cell activation and function by the adaptor protein CIN85. | Kong, MS., et al. 2019. Sci Signal. 12: PMID: 30723173
- The Pro-Oncogenic Adaptor CIN85 Acts as an Inhibitory Binding Partner of Hypoxia-Inducible Factor Prolyl Hydroxylase 2. | Kozlova, N., et al. 2019. Cancer Res. 79: 4042-4056. PMID: 31142511
- An anillin-CIN85-SEPT9 complex promotes intercellular bridge maturation required for successful cytokinesis. | Panagiotou, TC., et al. 2022. Cell Rep. 40: 111274. PMID: 36044846
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CIN85 Antibody (C-8) | sc-271567 | 200 µg/ml | $322.00 | |||
CIN85 Antibody (C-8): m-IgG Fc BP-HRP Bundle | sc-537663 | 200 µg Ab; 10 µg BP | $361.00 | |||
CIN85 Antibody (C-8): m-IgGκ BP-HRP Bundle | sc-534999 | 200 µg Ab; 40 µg BP | $361.00 | |||
CIN85 Antibody (C-8): m-IgG1 BP-HRP Bundle | sc-545292 | 200 µg Ab; 20 µg BP | $361.00 | |||
CIN85 (C-8) Neutralizing Peptide | sc-271567 P | 100 µg/0.5 ml | $69.00 |