Choriogonadotropin β Antibody (ME-107): sc-57067

Choriogonadotropin β Antibody (ME-107) is a mouse monoclonal IgG1 antibody that detects choriogonadotropin β in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Choriogonadotropin β plays a crucial role in early pregnancy by stimulating the ovaries to produce essential steroids, including estrogen and progesterone, which are vital for maintaining a healthy pregnancy. Choriogonadotropin β exists as a heterodimer, composed of a unique β chain that provides biological specificity and an α chain that is common to all gonadotropins. The unique β chain is encoded by a gene located on human chromosome 19, while the α subunit is mapped to chromosome 6. Proper functioning of choriogonadotropin β is essential not only for its role in reproductive health but also for its involvement in various signaling pathways that regulate ovarian function. Additionally, choriogonadotropin β is a member of the cystine knot growth-factor superfamily, characterized by a distinct arrangement of six cysteine residues, which is critical for structural integrity and biological activity. Anti-choriogonadotropin β antibody (ME-107) specifically recognizes choriogonadotropin β, making ME-107 an invaluable tool for research in reproductive biology and related fields.

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Choriogonadotropin β Antibody (ME-107) References:

1. Polyclonal antibodies against the polypeptide and carbohydrate epitopes of recombinant human choriogonadotropin beta-subunit.  |  Chen, W. and Bahl, OP. 1992. Mol Cell Endocrinol. 86: 57-66. PMID: 1380928
2. Delineation via site-directed mutagenesis of the carboxyl-terminal region of human choriogonadotropin beta required for subunit assembly and biological activity.  |  Chen, F. and Puett, D. 1991. J Biol Chem. 266: 6904-8. PMID: 1707877
3. Recombinant carbohydrate variant of human choriogonadotropin beta-subunit (hCG beta) descarboxyl terminus (115-145). Expression and characterization of carboxyl-terminal deletion mutant of hCG beta in the baculovirus system.  |  Chen, WY. and Bahl, OP. 1991. J Biol Chem. 266: 6246-51. PMID: 1848851
4. Determination of biological variation of α-fetoprotein and choriogonadotropin (β chain) in disease-free patients with testicular cancer.  |  Trapé, J., et al. 2010. Clin Chem Lab Med. 48: 1799-801. PMID: 20828364
5. Helix formation in reduced, S-carboxymethylated human choriogonadotropin beta subunit and tryptic peptides.  |  Puett, D. and Birken, S. 1989. J Protein Chem. 8: 779-94. PMID: 2483052
6. Characterization of a carboxyterminal peptide fragment of the human choriogonadotropin beta-subunit excreted in the urine of a woman with choriocarcinoma.  |  Amr, S., et al. 1983. J Clin Invest. 71: 329-39. PMID: 6185541
7. Evaluation of a solid-phase enzyme immunoassay for human choriogonadotropin beta subunit.  |  Davey, DD., et al. 1983. Clin Chem. 29: 1964-6. PMID: 6194917
8. Modification of the choriogonadotropin beta-subunit radioimmunoassay for determination of urinary choriogonadotropin.  |  McCready, J., et al. 1978. Clin Chem. 24: 1958-61. PMID: 709829
9. Circular dichroic and immunological properties of human choriogonadotropin- beta carboxyl terminal peptides.  |  Puett, D., et al. 1982. Int J Pept Protein Res. 19: 506-13. PMID: 7118421
10. Amino/carboxyl-terminal deletion mutants of human choriogonadotropin beta.  |  Huang, J., et al. 1993. J Biol Chem. 268: 9311-5. PMID: 7683647

The preferred Choriogonadotropin β antibody is Choriogonadotropin β Antibody (B-4): sc-271062.