CGRP Antibody (4901): sc-57053
- CGRP Antibody (4901) is a mouse monoclonal IgG1 κ CGRP antibody, cited in 57 publications, provided at 200 µg/ml
- raised against CGRP1 of rat origin
- CGRP Antibody (4901) is recommended for detection of CGRP1 and CGRP2 of mouse, rat, human and canine origin by WB, IP, IF and ELISA
- Anti-CGRP Antibody (4901) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to biotin for WB, IHC(P) and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for CGRP Antibody (4901) for WB applications. These reagents are now offered in bundles with CGRP Antibody (4901) (see ordering information below).
QUICK LINKS
CGRP Antibody (4901) is a mouse monoclonal IgG1 kappa light chain antibody that detects CGRP in mouse, rat, human, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CGRP (4901) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Calcitonin Gene-Related Peptide (CGRP) is a 37-amino acid neuropeptide that plays a crucial role in vasodilation and pain pathway modulation, making CGRP significant in migraine and other vascular disorders. CGRP (4901) monoclonal antibody detects this neuropeptide primarily in the central and peripheral nervous systems, where CGRP is synthesized and released from sensory neurons. CGRP presence in these locations is vital for mediating neurogenic inflammation and regulating blood flow, particularly in conditions such as migraine, where CGRP levels are often elevated. The CGRP gene, CALCA, undergoes alternative splicing to produce different isoforms, including CGRP1 and CGRP2, which exhibit distinct biological activities. Understanding CGRP localization and function is essential for developing targeted therapies for migraine and other related conditions, highlighting anti-CGRP antibody (4901) significance in research and clinical applications.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CGRP Antibody (4901) References:
- Skeletal effects of calcitonin in ovariectomized rats. | Wronski, TJ., et al. 1991. Endocrinology. 129: 2246-50. PMID: 1915104
- The second human calcitonin/CGRP gene is located on chromosome 11. | Höppener, JW., et al. 1985. Hum Genet. 70: 259-63. PMID: 2991116
- Expression in brain of a messenger RNA encoding a novel neuropeptide homologous to calcitonin gene-related peptide. | Amara, SG., et al. 1985. Science. 229: 1094-7. PMID: 2994212
- Calcitonin gene-related peptide (CGRP): role in migraine pathophysiology and therapeutic targeting. | Wattiez, AS., et al. 2020. Expert Opin Ther Targets. 24: 91-100. PMID: 32003253
- Pharmacokinetics, Pharmacodynamics and Drug-Drug Interactions of New Anti-Migraine Drugs-Lasmiditan, Gepants, and Calcitonin-Gene-Related Peptide (CGRP) Receptor Monoclonal Antibodies. | Szkutnik-Fiedler, D. 2020. Pharmaceutics. 12: PMID: 33287305
- Depression and treatment with anti-calcitonin gene related peptide (CGRP) (ligand or receptor) antibodies for migraine. | de Vries Lentsch, S., et al. 2024. Eur J Neurol. 31: e16106. PMID: 37847221
- The complete sequence of human preprocalcitonin. | Le Moullec, JM., et al. 1984. FEBS Lett. 167: 93-7. PMID: 6546550
- Calcitonin gene regulation in vivo. | Silver, J. and Naveh-Many, T. 1993. Horm Metab Res. 25: 470-2. PMID: 8225199
- High-resolution chromosomal localization of the human calcitonin/CGRP/IAPP gene family members. | Hoovers, JM., et al. 1993. Genomics. 15: 525-9. PMID: 8468047
- Calcitonin mRNA is produced in liver by two different splicing pathways. | Bracq, S., et al. 1997. Mol Cell Endocrinol. 128: 111-5. PMID: 9140082
- Amylin, calcitonin gene-related peptide, calcitonin, and adrenomedullin: a peptide superfamily. | Wimalawansa, SJ. 1997. Crit Rev Neurobiol. 11: 167-239. PMID: 9209829
- Alternative RNA processing--its role in regulating expression of calcitonin/calcitonin gene-related peptide. | Lou, H. and Gagel, RF. 1998. J Endocrinol. 156: 401-5. PMID: 9582495
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CGRP Antibody (4901) | sc-57053 | 200 µg/ml | $322.00 | |||
CGRP Antibody (4901): m-IgG Fc BP-HRP Bundle | sc-526893 | 200 µg Ab; 10 µg BP | $361.00 | |||
CGRP Antibody (4901): m-IgG1 BP-HRP Bundle | sc-532266 | 200 µg Ab; 20 µg BP | $361.00 | |||
CGRP Antibody (4901) AC | sc-57053 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CGRP Antibody (4901) HRP | sc-57053 HRP | 200 µg/ml | $322.00 | |||
CGRP Antibody (4901) FITC | sc-57053 FITC | 200 µg/ml | $336.00 | |||
CGRP Antibody (4901) PE | sc-57053 PE | 200 µg/ml | $349.00 | |||
CGRP Antibody (4901) Alexa Fluor® 488 | sc-57053 AF488 | 200 µg/ml | $364.00 | |||
CGRP Antibody (4901) Alexa Fluor® 546 | sc-57053 AF546 | 200 µg/ml | $364.00 | |||
CGRP Antibody (4901) Alexa Fluor® 594 | sc-57053 AF594 | 200 µg/ml | $364.00 | |||
CGRP Antibody (4901) Alexa Fluor® 647 | sc-57053 AF647 | 200 µg/ml | $364.00 | |||
CGRP Antibody (4901) Alexa Fluor® 680 | sc-57053 AF680 | 200 µg/ml | $364.00 | |||
CGRP Antibody (4901) Alexa Fluor® 790 | sc-57053 AF790 | 200 µg/ml | $364.00 | |||
CGRP Antibody (4901) B | sc-57053 B | 200 µg/ml | $320.00 |