아미노 산1372-1465 mapping within a C-terminal cytoplasmic domain of ATP7B of human 의하고 기원한다
안티-ATP7B 항체 (A-11)는 WB, IP, IF and ELISA으로 mouse, rat and human유래의 ATP7B isoforms a and b 를 감지하는 데에 추천한다.
IP를 위해 agarose ;WB, IHC(P) and ELISA를 위해 HRP ;또는 IF, IHC(P) and FCM를 위해 phycoerythrin or FITC 에 결합된 Anti-ATP7B 항체 (A-11)를 제공한다.
WB (RGB), IF, IHC(P) 와FCM, RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems에 사용가능한 Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647결합제품도 있습니다.
WB (NIR), IF와FCM,Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems에 사용가능한 Alexa Fluor® 680 or Alexa Fluor® 790 결합제품도 있습니다.
m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP) is the preferred detection reagent for ATP7B Antibody (A-11) for WB applications. This reagent is now offered in a bundle with ATP7B Antibody (A-11) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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ATP7B Antibody (A-11) is a high quality monoclonal ATP7B antibody (also designated ATP7B antibody) suitable for the detection of the ATP7B protein of mouse, rat and human origin. ATP7B Antibody (A-11) is available as both the non-conjugated anti-ATP7B antibody form, as well as multiple conjugated forms of anti-ATP7B antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The copper efflux transporters ATP7A and ATP7B sequester intracellular copper into the vesicular secretory pathway for export from the cell. ATP7A functions as a transmembrane copper-translocating P-type ATPase and plays a vital role in systemic copper absorption in the gut and copper reabsorption in the kidney. Polarized epithelial cells such as Madin-Darby canine kidney cells are a physiologically relevant model for systemic copper absorption and reabsorption in vivo. Although ATP7A is not detectable in most normal tissues, it is expressed in a considerable fraction of many common tumor types. Increased expression of ATP7A renders cells resistant to cisplatin and carboplatin. Mutations in the ATP7A gene result in Menkes disease, which is fatal in early childhood. Mutations in the ATP7B gene lead to the autosomal recessive disorder, Wilson disease, characterized by neurological symptoms and hepatic damage.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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