Date published: 2026-4-23

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Ara-G (CAS 38819-10-2)

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Alternate Names:
9-β-D-Arabinofuranosyl guanine
Application:
Ara-G is an inducer of apoptosis, inhibitor of DNA synthesis, an antimetabolite, and antineoplastic
CAS Number:
38819-10-2
Purity:
≥97%
Molecular Weight:
283.24
Molecular Formula:
C10H1315N5O5•H2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Ara-G is a compound with applications in biochemical research, particularly in the field of nucleosides and nucleotides. It is an analog of guanine and is used to study the mechanisms of nucleoside incorporation into nucleic acids. Ara-G serves as a substrate in enzymatic reactions involving kinases, which phosphorylate the compound to generate nucleotide analogs that can be incorporated into DNA or RNA. These studies help researchers understand the specificity and kinetics of nucleoside kinases and their role in cellular metabolism. Additionally, Ara-G is utilized in the investigations where it may interfere with the synthesis of genetic material. In molecular biology research, the compound is investigated for its effects on gene expression and the replication of genetic material.


Ara-G (CAS 38819-10-2) References

  1. [Not Available].  |  Courtois, Y., et al. 1969. FEBS Lett. 3: 330-332. PMID: 11947041
  2. Arabinosylguanine is phosphorylated by both cytoplasmic deoxycytidine kinase and mitochondrial deoxyguanosine kinase.  |  Rodriguez, CO., et al. 2002. Cancer Res. 62: 3100-5. PMID: 12036920
  3. Resistance to mitochondrial- and Fas-mediated apoptosis in human leukemic cells with acquired resistance to 9-beta-D-arabinofuranosylguanosine.  |  Månsson, E., et al. 2002. Biochem Biophys Res Commun. 298: 338-44. PMID: 12413945
  4. Nelarabine: a novel purine antimetabolite antineoplastic agent.  |  Buie, LW., et al. 2007. Clin Ther. 29: 1887-99. PMID: 18035189
  5. Nelarabine for the treatment of patients with relapsed or refractory T-cell acute lymphoblastic leukemia or lymphoblastic lymphoma.  |  DeAngelo, DJ. 2009. Hematol Oncol Clin North Am. 23: 1121-35, vii-viii. PMID: 19825456
  6. A new high-performance liquid chromatography method determines low production of 9-beta-D-arabinofuranosylguanine triphosphate, an active metabolite of nelarabine, in adult T-cell leukemia cells.  |  Yamauchi, T., et al. 2010. Oncol Rep. 23: 499-504. PMID: 20043113
  7. Profile of nelarabine: use in the treatment of T-cell acute lymphoblastic leukemia.  |  Reilly, KM. and Kisor, DF. 2009. Onco Targets Ther. 2: 219-28. PMID: 20616909
  8. Synthesis of 2'-deoxy-2'-[18F]fluoro-9-β-D-arabinofuranosylguanine: a novel agent for imaging T-cell activation with PET.  |  Namavari, M., et al. 2011. Mol Imaging Biol. 13: 812-8. PMID: 20838911
  9. Combination of guanine arabinoside and Bcl-2 inhibitor YC137 overcomes the cytarabine resistance in HL-60 leukemia cell line.  |  Nishi, R., et al. 2013. Cancer Sci. 104: 502-7. PMID: 23320492
  10. A nelarabine-resistant T-lymphoblastic leukemia CCRF-CEM variant cell line is cross-resistant to the purine nucleoside phosphorylase inhibitor forodesine.  |  Yamauchi, T., et al. 2014. Anticancer Res. 34: 4885-92. PMID: 25202070
  11. Hyper-CVAD plus nelarabine in newly diagnosed adult T-cell acute lymphoblastic leukemia and T-lymphoblastic lymphoma.  |  Abaza, Y., et al. 2018. Am J Hematol. 93: 91-99. PMID: 29047158
  12. Metabolism and selective cytotoxicity of 9-beta-D-arabinofuranosylguanine in human lymphoblasts.  |  Shewach, DS., et al. 1985. Cancer Res. 45: 1008-14. PMID: 3971358
  13. Arabinosyl nucleosides. XXXII. Mechanism of inhibition of L5178y mouse lymphoma cells by 9-beta-D-arabinofuranosylguanine.  |  Müller, WE., et al. 1981. Chem Biol Interact. 34: 301-13. PMID: 7460088

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Ara-G, 5 mg

sc-214548
5 mg
$156.00

Ara-G, 25 mg

sc-214548A
25 mg
$582.00