Apelin Antibody (2A1-2D5): sc-293441

Apelin Antibody (2A1-2D5) is a mouse monoclonal IgG1 kappa light chain antibody that detects the Apelin protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Apelin antibody (2A1-2D5) is available as the non-conjugated format. Apelin (APEL) serves as an endogenous ligand for the APJ receptor and acts as an alternate coreceptor with CD4 during HIV-1 infection, playing a crucial role in inhibiting HIV-1 entry into cells that express both APJ and CD4. Apelin protein undergoes proteolytic processing, resulting in the generation of several active peptides, including Apelin-36, which is currently being studied as a potential plasma marker for cardiopulmonary disease. Notably, Apelin is predominantly expressed in the brain, particularly in regions such as the thalamus, frontal cortex, hypothalamus, and midbrain, highlighting its significance in central nervous system functions. Additionally, Apelin is secreted by the mammary gland into colostrum and milk, suggesting that oral intake of Apelin during early life may play a vital role in modulating immune responses in neonates and newborns. Furthermore, Apelin has been identified as a potent stimulator of cardiac contractility, indicating its potential involvement in the regulation of the cardiovascular system.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

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Apelin Antibody (2A1-2D5) References:

1. Apelin, the natural ligand of the orphan receptor APJ, is abundantly secreted in the colostrum.  |  Habata, Y., et al. 1999. Biochim Biophys Acta. 1452: 25-35. PMID: 10525157
2. Characterization of apelin, the ligand for the APJ receptor.  |  Lee, DK., et al. 2000. J Neurochem. 74: 34-41. PMID: 10617103
3. Apelin, the natural ligand of the orphan seven-transmembrane receptor APJ, inhibits human immunodeficiency virus type 1 entry.  |  Cayabyab, M., et al. 2000. J Virol. 74: 11972-6. PMID: 11090199
4. Regulation of apelin mRNA expression by insulin and glucocorticoids in mouse 3T3-L1 adipocytes.  |  Wei, L., et al. 2005. Regul Pept. 132: 27-32. PMID: 16137778
5. Apelin: a new plasma marker of cardiopulmonary disease.  |  Goetze, JP., et al. 2006. Regul Pept. 133: 134-8. PMID: 16263185
6. Apelin protects myocardial injury induced by isoproterenol in rats.  |  Jia, YX., et al. 2006. Regul Pept. 133: 147-54. PMID: 16278022
7. Apelin+ Endothelial Niche Cells Control Hematopoiesis and Mediate Vascular Regeneration after Myeloablative Injury.  |  Chen, Q., et al. 2019. Cell Stem Cell. 25: 768-783.e6. PMID: 31761723
8. Neuroprotective Roles of Apelin-13 in Neurological Diseases.  |  Zhang, Y., et al. 2023. Neurochem Res. 48: 1648-1662. PMID: 36745269
9. Targeting the apelin system for the treatment of cardiovascular diseases.  |  Chapman, FA., et al. 2023. Cardiovasc Res. 119: 2683-2696. PMID: 37956047
10. Structure-based design of non-hypertrophic apelin receptor modulator.  |  Wang, WW., et al. 2024. Cell. 187: 1460-1475.e20. PMID: 38428423
11. Apelin modulates inflammation and leukocyte recruitment in experimental autoimmune encephalomyelitis.  |  Park, H., et al. 2024. Nat Commun. 15: 6282. PMID: 39060233
12. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor.  |  Tatemoto, K., et al. 1998. Biochem Biophys Res Commun. 251: 471-6. PMID: 9792798

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Apelin Antibody (2A1-2D5) has 9 citations in a variety of scientific publications.

Primary antibodies like Anti-Apelin Antibody (2A1-2D5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Apelin Antibody (2A1-2D5) Specifications

Alternate Product Name: Apelin

Product Clone Name: 2A1-2D5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-122

Epitope Target: Apelin

Epitope Species: human

Product Reactivity/Detection: Apelin

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 9 citations in various scientific publications

Available Conjugates/Forms for Apelin Antibody (2A1-2D5): N/A