Molecular structure of Anandamide, CAS Number: 94421-68-8
Anandamide (CAS 94421-68-8)
See product citations (2)
Alternate Names:
AEA; N-Arachidonoylethanolamine; (all-Z)-N-(2-Hydroxyethyl)-5,8,11,14-eicosatetraenamide
Application:
Anandamide is an endogenous cannabinoid receptor ligand
CAS Number:
94421-68-8
Molecular Weight:
347.53
Molecular Formula:
C22H37NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Anandamide is an endogenous cannabinoid (CB) ligand that binds to brain and peripheral cannabinoid receptors (CB1: Ki=52nm CB2: Ki=1930nm) and VR1 (Ki=5.78muM), inhibits the binding of [3H]HU-243 to synaptosomal membranes (Ki=52 nM), and inhibits NF-kappaB activation through direct binding to IKKbeta. Some other reported effects of Anandamide are: production of hypothermia and analgesia in mice, decrease in spontaneous motor activity, activation of the MAP kinase (MAPK/ERK) signalling pathway, induction of apoptosis independently of cannabinoid or vanilloid receptors, and inhibition of human breast cancer cell proliferation and migration of tumor cells and T lymphocytes. Additional forms available: sc-200790 (dissolved in solvent) Anandamide is an activator of GPR55.
Anandamide (CAS 94421-68-8) References
- Simulation of Swanson's literature-based discovery: anandamide treatment inhibits growth of gastric cancer cells in vitro and in silico. | Dong, W., et al. 2014. PLoS One. 9: e100436. PMID: 24949851
- Sperm Release From the Oviductal Epithelium Depends on Ca(2+) Influx Upon Activation of CB1 and TRPV1 by Anandamide. | Gervasi, MG., et al. 2016. J Cell Biochem. 117: 320-33. PMID: 26129689
- On the effects of CP 55-940 and other cannabinoid receptor agonists in C6 and U373 cell lines. | Ortega, A., et al. 2015. Toxicol In Vitro. 29: 1941-51. PMID: 26255146
- Important role of endocannabinoid signaling in the development of functional vision and locomotion in zebrafish. | Martella, A., et al. 2016. FASEB J. 30: 4275-4288. PMID: 27623930
- High-throughput screening and bioinformatic analysis to ascertain compounds that prevent saturated fatty acid-induced β-cell apoptosis. | Lee, SH., et al. 2017. Biochem Pharmacol. 138: 140-149. PMID: 28522407
- Intestinal P-glycoprotein exports endocannabinoids to prevent inflammation and maintain homeostasis. | Szabady, RL., et al. 2018. J Clin Invest. 128: 4044-4056. PMID: 30102254
- High Fat Diet Increases Circulating Endocannabinoids Accompanied by Increased Synthesis Enzymes in Adipose Tissue. | Kuipers, EN., et al. 2018. Front Physiol. 9: 1913. PMID: 30687125
- Hypothalamic endocannabinoids inversely correlate with the development of diet-induced obesity in male and female mice. | Miralpeix, C., et al. 2019. J Lipid Res. 60: 1260-1269. PMID: 31138606
- Celastrol is a novel selective agonist of cannabinoid receptor 2 with anti-inflammatory and anti-fibrotic activity in a mouse model of systemic sclerosis. | Jiang, X., et al. 2020. Phytomedicine. 67: 153160. PMID: 31901889
- In vitro and in vivo pharmacological evaluation of the synthetic cannabinoid receptor agonist EG-018. | Gamage, TF., et al. 2020. Pharmacol Biochem Behav. 193: 172918. PMID: 32247816
- Endocannabinoid Receptor-1 and Sympathetic Nervous System Mediate the Beneficial Metabolic Effects of Gastric Bypass. | Ye, Y., et al. 2020. Cell Rep. 33: 108270. PMID: 33113371
- Gut microbiota regulation of P-glycoprotein in the intestinal epithelium in maintenance of homeostasis. | Foley, SE., et al. 2021. Microbiome. 9: 183. PMID: 34493329
- Differences in neurotoxic outcomes of organophosphorus pesticides revealed via multi-dimensional screening in adult and regenerating planarians. | Ireland, D., et al. 2022. Front Toxicol. 4: 948455. PMID: 36267428
- A zebrafish HCT116 xenograft model to predict anandamide outcomes on colorectal cancer. | Maradonna, F., et al. 2022. Cell Death Dis. 13: 1069. PMID: 36564370
Inhibitor of:
IKK.Activator of:
CB1, CB2, GPR55, and VR1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Anandamide, 5 mg | sc-396321 | 5 mg | $81.00 | |||
Anandamide, 25 mg | sc-396321A | 25 mg | $219.00 | |||
Anandamide, 500 mg | sc-396321B | 500 mg | $4068.00 | |||
Anandamide, 1 g | sc-396321C | 1 g | $7813.00 |