Ambroxol hydrochloride CAS: 23828-92-4
MF: C13H18Br2N2O•HCl
MW: 414.6
An expectorant antioxidant and antiinflammatory agent.

Ambroxol hydrochloride (CAS 23828-92-4)

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Application An expectorant antioxidant and antiinflammatory agent
CAS 등록번호: 23828-92-4
순도: 98%
분자량: 414.6
분자식: C13H18Br2N2O•HCl
* 참조분석증명서대량의 측정 데이터(함수량포함).
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Ambroxol hydrochloride is a small molecule expectorant and mucolytic agent with antioxidant and antiinflammatory effects. Ambroxol stimulates the secretion of surfactant which decreases mucus adhesion to the bronchial lining and produces expectorant effects. The antioxidant effects of Ambroxol are well demonstrated, where lipid peroxidation initiated by t-butyl hydroperoxide or doxorubicin is suppressed in the presence Ambroxol, and scavenging of hydroxyl radicals and cellular superoxide radical anions is also observed. Ambroxol produces antiinflammatory effects by blocking the expression of proinflammatory messengers, inhibiting the release of histamine from mast cells and the generation of cytokines and interleukins. Ambroxol hydrochloride is an inhibitor of Sodium Channel Protein.


References

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4. Gibbs, B.F., et al. 1999. Inflamm. Res. 48: 86-93. PMID: 10202994
5. Stetinová, V., et al. 2004. Clin. Exp. Med. 4: 152-158. PMID: 15599665
6. Laurent, A., et al. 2004. Hepatology. 39: 1277-1285. PMID: 15122756
7. Su, X., et al. 2004. Intensive Care Med. 30: 133-140. PMID: 14504727
8. Beeh, K.M., et al. 2008. Eur. J. Med. Res. 13: 557-562. PMID: 19073395
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Appearance :
Crystalline powder
Physical State :
Solid
용해도 :
Soluble in methanol, water (~5 mg/ml), ethanol (~5 mg/ml), and DMSO (50 mM). Insoluble in ether.
저장 :
Store at 4° C
녹는점 :
>235° C (dec.)
IC50 :
tetrodotoxin (TTX)-resistant channels: IC50 = 35.2 µM; TTX-sensitive subtypes: IC50 = 111.5 µM
pK Values :
pKb: 8.69
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
WGK Germany :
3
RTECS :
GV8423000
PubChem CID :
108013
Merck Index :
14: 386
MDL Number :
MFCD00078932
EC Number :
242-500-3
SMILES :
C1CC(CCC1NCC2=CC(=CC(=C2N)Br)Br)O.Cl

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