alpha-actinin-4 Antibody (B-11): sc-390180
- α-actinin-4 Antibody (B-11) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 610-660 mapping within an internal region of α-actinin-4 of human origin
- recommended for detection of α-actinin-4 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgGκ BP-HRP is the preferred secondary detection reagent for α-actinin-4 Antibody (B-11) for WB and IHC(P) applications. This reagent is now offered in a bundle with α-actinin-4 Antibody (B-11) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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α-actinin-4 Antibody (B-11) is a mouse monoclonal IgG2a antibody that detects α-actinin-4 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). α-actinin-4 is a crucial cytoskeletal protein that plays a significant role in maintaining cellular structural integrity by cross-linking actin filaments, which is essential for cellular shape and motility. α-actinin-4 is predominantly located in the cytoskeleton of muscle and non-muscle cells, including skeletal, cardiac, and smooth muscle cells, where anti-α-actinin-4 antibody (B-11) contributes to studying the organization of the actin cytoskeleton. Proper localization and function of α-actinin-4 are vital for various cellular processes, including muscle contraction and cell signaling. Mutations in the gene encoding α-actinin-4 have been linked to focal segmental glomerulosclerosis 1 (FSGS1), a serious renal condition characterized by progressive kidney dysfunction and potential renal failure. α-actinin-4 (B-11) antibody serves as an invaluable tool for researchers studying cytoskeletal dynamics and implications in health and disease.
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alpha-actinin-4 Antibody (B-11) References:
- Extra-cellular matrix proteins induce re-distribution of alpha-actinin-1 and alpha-actinin-4 in A431 cells. | Bolshakova, A., et al. 2007. Cell Biol Int. 31: 360-5. PMID: 17336103
- Modulating alpha-actinin-4 dynamics in podocytes. | Michaud, JL., et al. 2009. Cell Motil Cytoskeleton. 66: 166-78. PMID: 19206166
- The role of alpha-actinin-4 in human kidney disease. | Feng, D., et al. 2015. Cell Biosci. 5: 44. PMID: 26301083
- Proteostasis as a therapeutic target in glomerular injury associated with mutant α-actinin-4. | Yee, A., et al. 2018. Am J Physiol Renal Physiol. 315: F954-F966. PMID: 29873512
- Binding Dynamics of α-Actinin-4 in Dependence of Actin Cortex Tension. | Hosseini, K., et al. 2020. Biophys J. 119: 1091-1107. PMID: 32853564
- Changes in the levels of α-actinin-4 in differentiating human myeloid leukemia cells induced by retinoic acid. | Saito, D., et al. 2021. Biochim Biophys Acta Mol Cell Res. 1868: 118968. PMID: 33454316
- Interaction of influenza A virus NS1 and cytoskeleton scaffolding protein α-actinin 4. | Zeng, Y., et al. 2022. Virus Genes. 58: 15-22. PMID: 34727338
- α-Actinin-4 drives invasiveness by regulating myosin IIB expression and myosin IIA localization. | Barai, A., et al. 2021. J Cell Sci. 134: PMID: 34730180
- Complementary Nck1/2 Signaling in Podocytes Controls α Actinin-4-Mediated Actin Organization, Adhesion, and Basement Membrane Composition. | Martin, CE., et al. 2022. J Am Soc Nephrol. 33: 1546-1567. PMID: 35906089
- Mesenchymal β-catenin signaling affects palatogenesis by regulating α-actinin-4 and F-actin. | Wang, X., et al. 2023. Oral Dis. 29: 3493-3502. PMID: 36251469
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
α-actinin-4 Antibody (B-11) | sc-390180 | 200 µg/ml | $322.00 | |||
α-actinin-4 Antibody (B-11): m-IgGκ BP-HRP Bundle | sc-552160 | 200 µg Ab; 40 µg BP | $361.00 |