Aloisine A (CAS 496864-16-5)

건강 상태 :

Solid

용해도 :

Soluble in DMSO (>10 mg/ml), and methanol. Insoluble in water.

저장 :

Store at -20° C

녹는점 :

281-283° C

비등점 :

459.64° C (Predicted)

밀도 :

1.23 g/cm³ (Predicted)

굴절률 :

n²⁰_D 1.66 (Predicted)

IC50 :

Cdk1/cyclin B: IC₅₀ = 150 nM; Cdk2/cyclin A: IC₅₀ = 120 nM; Cdk2/cyclin E: IC₅₀ = 400 nM; Cdk5/p25: IC₅₀ = 200 nM; GSK-3a: IC₅₀ = 500 nM; GSK-3β: IC₅₀ = 650 nM; JNK: IC₅₀ = ~3-10 µM; CDK5/p35: IC₅₀ = 160 nM; c-raf: IC₅₀ = ≥100 µM; CK1: IC₅₀ = ≥100 µM; CK2: IC₅₀ = ≥100 µM; MAPKK: IC₅₀ = ≥100 µM; PKA: IC₅₀ = ≥100 µM; PKG: IC₅₀ = ≥100 µM; PKCs: IC₅₀ = ≥100 µM; CFTR-dependent iodide efflux: EC₅₀50 = 150 nM (wtCFTR-CHO cells); CFTR-dependent iodide efflux: EC₅₀50 = 140 nM (Calu-3 cells); CFTR-dependent iodide efflux: EC₅₀50 = 111 nM (F508del-CFTR-CF15 cells); undifferentiated human teratocarcinoma cells NT2: IC₅₀ = 7 µM; differentiated postmitotic neurons hNT: IC₅₀ = 10.5 µM

pK 값 :

pK_a: 9.67, pK_b: 3.47

WGK 독일 :

3

PubChem CID :

MDL 번호 :

MFCD04973541

SMILES :

CCCCC1=C(NC2=C1N=CC=N2)C1=CC=C(O)C=C1