AK4 Antibody (A-9): sc-271161

AK4 Antibody (A-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects AK4 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). AK4 (A-9) antibody is available in both non-conjugated and multiple conjugated forms, such as agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates. AK4 plays a crucial role in cellular energy metabolism by catalyzing the conversion of adenine nucleotides, which are vital for energy transfer within cells. Specifically, AK4 is involved in the phosphorylation of adenosine diphosphate (ADP) to adenosine triphosphate (ATP), thereby influencing metabolic pathways that regulate gene expression, ion channel activity, and protein kinase signaling. AK4 mRNA is expressed as a 223 amino acid protein from the middle stage of embryogenesis through adulthood in the central nervous system, highlighting its significance in both development and adult physiology. Inherited mutations that lead to deficiencies in adenylate kinases, including AK4, have been associated with conditions such as hemolytic anemia, underscoring the importance of AK4 in maintaining cellular energy homeostasis.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

AK4 Antibody (A-9) References:

1. Adenylate kinase phosphotransfer communicates cellular energetic signals to ATP-sensitive potassium channels.  |  Carrasco, AJ., et al. 2001. Proc Natl Acad Sci U S A. 98: 7623-8. PMID: 11390963
2. Adenylate kinase: kinetic behavior in intact cells indicates it is integral to multiple cellular processes.  |  Dzeja, PP., et al. 1998. Mol Cell Biochem. 184: 169-82. PMID: 9746320
3. Identification of a novel adenylate kinase system in the brain: cloning of the fourth adenylate kinase.  |  Yoneda, T., et al. 1998. Brain Res Mol Brain Res. 62: 187-95. PMID: 9813319

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-AK4 Antibody (A-9) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-AK4 Antibody (A-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

AK4 Antibody (A-9) Specifications

Alternate Product Name: AK4

Product Clone Name: A-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 58-83

Epitope Target: AK4

Epitope Species: human

Product Reactivity/Detection: AK4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for AK4 Antibody (A-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin