Molecular structure of AG-370, CAS Number: 134036-53-6
AG-370 (CAS 134036-53-6)
Alternate Names:
Tyrphostin AG 370
Application:
AG-370 is a selective inhibitor of PDGFR kinase
CAS Number:
134036-53-6
Purity:
>95% (cis/trans mixture)
Molecular Weight:
259.27
Molecular Formula:
C15H9N5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
AG-370 is a protein tyrosine kinase (PTK) inhibitor that shows potential antiproliferative agents for diseases effected by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds, selectively inhibiting PTKs of key growth factors like epidermal growth factor (EGF) or platelet-derived growth factor (PDGF) through blocking of the phosphorylation of specific tyrosine residues. AG-370 is a selective inhibitor of PDGFR kinase. It displays comparatively weak inhibition of the EGF receptor.
AG-370 (CAS 134036-53-6) References
- Inhibition of platelet-derived growth factor-induced mitogenesis and tyrosine kinase activity in cultured bone marrow fibroblasts by tyrphostins. | Bryckaert, MC., et al. 1992. Exp Cell Res. 199: 255-61. PMID: 1312007
- Tyrphostins as molecular tools and potential antiproliferative drugs. | Levitzki, A. and Gilon, C. 1991. Trends Pharmacol Sci. 12: 171-4. PMID: 1862529
- Differentiating human multipotent mesenchymal stromal cells regulate microRNAs: prediction of microRNA regulation by PDGF during osteogenesis. | Goff, LA., et al. 2008. Exp Hematol. 36: 1354-1369. PMID: 18657893
- Interdependence of platelet-derived growth factor and estrogen-signaling pathways in inducing neonatal rat testicular gonocytes proliferation. | Thuillier, R., et al. 2010. Biol Reprod. 82: 825-36. PMID: 20089883
- Intrinsic regulation of hemangioma involution by platelet-derived growth factor. | Roach, EE., et al. 2012. Cell Death Dis. 3: e328. PMID: 22717583
- Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. | Gazit, A., et al. 1989. J Med Chem. 32: 2344-52. PMID: 2552117
- PDGFRα mediated survival of myofibroblasts inhibit satellite cell proliferation during aberrant regeneration of lacerated skeletal muscle. | Thooyamani, AS. and Mukhopadhyay, A. 2021. Sci Rep. 11: 63. PMID: 33420132
- Bioinformatic Analysis for Potential Biomarkers and Therapeutic Targets of T2DM-related MI. | Li, C. and Liu, Z. 2021. Int J Gen Med. 14: 4337-4347. PMID: 34413670
- A new molecular subclassification and in silico predictions for diagnosis and prognosis of papillary thyroid cancer by alternative splicing profile. | Li, H., et al. 2023. Front Pharmacol. 14: 1119789. PMID: 36950012
- Editorial: Therapeutic targeting of splicing variants in cancer. | Sarvari, P., et al. 2023. Front Pharmacol. 14: 1206342. PMID: 37214461
Inhibitor of:
PDGFR, and Tyrosine Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AG-370, 1 mg | sc-205203 | 1 mg | $94.00 | |||
AG-370, 10 mg | sc-205203A | 10 mg | $408.00 |