Molecular structure of A-366, CAS Number: 1527503-11-2
A-366 (CAS 1527503-11-2)
Alternate Names:
5′-methoxy-6′-[3-(1-pyrrolidinyl)propoxy]-spiro[cyclobutane-1,3′-[3H]indol]-2′-amine
CAS Number:
1527503-11-2
Molecular Weight:
329.4
Molecular Formula:
C19H27N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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A-366 (CAS 1527503-11-2) References
- The Histone Methyltransferase Inhibitor A-366 Uncovers a Role for G9a/GLP in the Epigenetics of Leukemia. | Pappano, WN., et al. 2015. PLoS One. 10: e0131716. PMID: 26147105
- In vivo administration of G9a inhibitor A366 decreases osteogenic potential of bone marrow-derived mesenchymal stem cells. | Khanban, H., et al. 2019. EXCLI J. 18: 300-309. PMID: 31338003
- Epigenetic Regulation of Vascular Smooth Muscle Cells by Histone H3 Lysine 9 Dimethylation Attenuates Target Gene-Induction by Inflammatory Signaling. | Harman, JL., et al. 2019. Arterioscler Thromb Vasc Biol. 39: 2289-2302. PMID: 31434493
- The histone methyltransferase inhibitor A-366 enhances hemoglobin expression in erythroleukemia cells upon co-exposure with chemical inducers in culture. | Papagiannopoulos, CI., et al. 2021. J Biol Res (Thessalon). 28: 2. PMID: 33407944
- Augmented Production of Platelets From Cord Blood With Euchromatic Histone Lysine Methyltransferase Inhibition. | Liu, Y., et al. 2022. Stem Cells Transl Med. 11: 946-958. PMID: 35880582
- Single-cell multiomics sequencing reveals the reprogramming defects in embryos generated by round spermatid injection. | Wang, J., et al. 2022. Sci Adv. 8: eabm3976. PMID: 35947654
- G9a/GLP inhibition during ex vivo lymphocyte expansion increases in vivo cytotoxicity of engineered T cells against hepatocellular carcinoma. | Lam, MSY., et al. 2023. Nat Commun. 14: 563. PMID: 36732506
- Loss of renal tubular G9a benefits acute kidney injury by lowering focal lipid accumulation via CES1. | Yang, D., et al. 2023. EMBO Rep. 24: e56128. PMID: 37042626
- Euchromatic Histone Lysine Methyltransferase 2 Inhibition Enhances Carfilzomib Sensitivity and Overcomes Drug Resistance in Multiple Myeloma Cell Lines. | Mereu, E., et al. 2023. Cancers (Basel). 15: PMID: 37190128
- Inhibition of EHMT1/2 rescues synaptic damage and motor impairment in a PD mouse model. | Zhang, Z., et al. 2024. Cell Mol Life Sci. 81: 128. PMID: 38472451
Inhibitor of:
BRPF3, Dimethyl Histone H3, EHM2, EHMT1, G9a, GLT8D3, HEATR5A, hIws1, KMT5 (lysine methyltransferase), KTELC1, LOC439994, Menin, Monomethyl Histone H4, MPc2, MSL3L2, p300, PA1, SAMD4A, Snf2, SUV39H1, TGIF2, ZBTB44, Zfp78, ZNF197, ZNF198, ZNF250, ZNF251, ZNF334, ZNF337, ZNF34, ZNF341, ZNF343, ZNF445, ZNF502, ZNF508, ZNF519, ZNF532, ZNF541, ZNF572, ZNF619, ZNF621, and ZNF623.Activator of:
BAZ2B, C1orf69, Histone cluster 1 H2BB, INTS4, L3MBTL4, and Mel-18.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
A-366, 10 mg | sc-507495 | 10 mg | $195.00 |