Molecular structure of 6-Acetyl-1H-indazole, CAS Number: 189559-85-1
6-Acetyl-1H-indazole (CAS 189559-85-1)
Alternate Names:
1-(1H-Indazol-6-yl)-ethanone
CAS Number:
189559-85-1
Molecular Weight:
160.18
Molecular Formula:
C9H8N2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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6-Acetyl-1H-indazole serves as a pivotal starting material for the synthesis of various compounds. The indazole core is a common motif in molecules exhibiting a wide range of biological effects, and the modification at the 6th position with an acetyl group can be a strategy to modulate these effects or improve the compound′s kinetic properties. It acs as an inhibitor of cyclooxygenase-2 (COX-2), an enzyme involved in the production of pro-inflammatory mediators. Beyond its COX-2 inhibitory activity, 6-Acetyl-1H-indazole has demonstrated inhibitory effects on various other enzymes. These include aldose reductase, lipoxygenase, and thromboxane synthase, which are involved in diverse biochemical pathways.
6-Acetyl-1H-indazole (CAS 189559-85-1) References
- N-Phenylpyridine-3-Carboxamide and 6-Acetyl-1H-Indazole Inhibit the RNA Replication Step of the Dengue Virus Life Cycle. | Sow, AA., et al. 2023. Antimicrob Agents Chemother. 67: e0133122. PMID: 36700643
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| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
6-Acetyl-1H-indazole, 100 mg | sc-473364 | 100 mg | $272.00 |