3-Keto Valproic Acid Sodium Salt 3-Keto Valproic Acid Sodium Salt is a useful main metabolite of Valproic Acid.

3-Keto Valproic Acid Sodium Salt (CAS 1184991-15-8)

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Alternate Names: 3-keto-VPA; 3-oxo-2-propyl-pentanoic Acid Sodium Salt; 2-Propyl-3-oxopentanoic Acid Sodium Salt;
Application 3-Keto Valproic Acid Sodium Salt is a useful main metabolite of Valproic Acid
CAS 등록번호: 1184991-15-8
순도: ≥95%
분자량: 180.18
분자식: C8H13NaO3
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* Refer to Certificate of Analysis for lot specific data (including water content).

3-Keto Valproic Acid Sodium Salt is the sodium salt of the main metabolite of Valproic Acid. 3-Keto Valproic Acid is produced from Valproic Acid metabolism by β-oxidation and may be useful for monitoring the metabolism of Valproic Acid in vitro . The parent compound, Valproic Acid, is a branched chain, fatty acid which is reported to potentially enhance central GABAergic neurotransmission and inhibit Na+ channels. Currently, the various molecular mechanisms of action of Valproic Acid have not been completely elucidated. Valproic Acid has been reported to be a potent inhibitor of histone deacetylases (HDACs) in vitro. Valproic Acid is also noted to relieve HDAC-dependent transcriptional repression and causes the hyperacetylation of histones in cultured cells. In animal studies, Valproic Acid has been observed to reduce tumor growth and metastasis formation. Additionally, Valproic Acid is reported to activate Wnt-dependent gene expression and to mimic trichostatin A (sc-3511) in the inhibition of histone deacetylase.

Metabolites of Valproic Acid are also available as:
Valproic Acid (sc-213144)
Valproic Acid, Sodium Salt (sc-202378)
3-Hydroxy Valproic Acid (sc-209599)
4-Hydroxy Valproic Acid Sodium Salt(Mixture of Diastereomers) (sc-216870)
rac 5-Hydroxy Valproic Acid Sodium Salt (sc-208266)
Valproic Acid β-D-Glucuronide Allyl Ester (sc-220360)
Valproic Acid β-D-Glucuronide (sc-213145)

Labelled forms of Valproic Acid are available as:
Valproic Acid-d6 (sc-213146)
Valproic Acid-d6 β-D-Glucuronide (sc-220361)
rac 5-Hydroxy Valproic Acid-d7 Sodium Salt (sc-219789)


References

1. Böhles, H., et al. 1982. Eur. J. Pediatr. 139: 185-186. PMID: 6819143

2. Burchell, B., et al. 1989. Dev Pharmacol Ther. 13: 70-77. PMID: 2515047

3. Bjorge, S.M. and Baillie, T.A. 1991. Drug Metab. Dispos. 19: 823-829. PMID: 1680661

4. Rettie, A.E., et al. 1995. Biochemistry. 34: 7889-7895. PMID: 7794900

5. Bello-Ramírez, A.M., et al. 2002. Epilepsia. 43: 475-481. PMID: 12027907

Physical State :
Solid
저장 :
Store at -20° C
녹는점 :
>250° C (dec.)
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
PubChem CID :
45039635
SMILES :
CCCC(C(=O)CC)C(=O)[O-].[Na+]

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