3-Hydroxyanthranilic acid CAS: 548-93-6
MF: C7H7NO3
MW: 153.14

3-Hydroxyanthranilic acid (CAS 548-93-6)

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Alternate Names: 3-Hydroxyanthranilic acid is also known as 2-Amino-3-hydroxybenzoic acid.
Application 3-Hydroxyanthranilic acid is a tryptophan metabolite along the kynurenine pathway, shown to induce apoptosis in T cells.
CAS 등록번호: 548-93-6
순도: ≥95%
분자량: 153.14
분자식: C7H7NO3
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* Refer to Certificate of Analysis for lot specific data (including water content).

3-Hydroxyanthranilic acid is a tryptophan metabolite along the kynurenine pathway. 3-Hydroxyanthranilic acid has been shown to induce apoptosis in T cells. In macrophages, 3-Hydroxyanthranilic acid has been shown to inhibit nitric oxide synthase and to stimulate TGF-β production.


References

1. Stone, T.W., Stoy, N., and Darlington, L.G.An expanding range of targets for kynurenine metabolites of tryptophan. Trends in Pharamacological Sciences 34(2), 136-143 (2013).
2. Thomas, S.R., Wittig, P.K., and Stocker, R.3-Hydroxyanthranilic acid is an efficient, cell-derived co-antioxidant for α-tocopherol, inhibiting human low density lipoprotein and plasma lipid peroxidation. The Journal of Biological Chemisty 271, 32714-32721 (1996).

Appearance :
Powder
Physical State :
Solid
용해도 :
Soluble in 1N HCl (10 mg/ml), water (partly), ether, chloroform, and alcohols.
저장 :
Store at room temperature
녹는점 :
240° C (lit.)(dec.)
비등점 :
~356.9° C at 760 mmHg (Predicted)
밀도 :
~1.5 g/cm3 (Predicted)
굴절률 :
n20D 1.69 (Predicted)
IC50 :
Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase: IC50 = 1.44 µM (Plasmodium berghei); Protein RecA: EC5050 = 5.43 µM (Mycobacterium tuberculosis); G6PD: IC50 = 24 µM (human)
pK Values :
pKa: 2.08 (Predicted)
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
WGK Germany :
3
RTECS :
DG2625000
PubChem CID :
86
MDL Number :
MFCD00007700
EC Number :
208-962-5
Beilstein Registry :
0973356
SMILES :
C1=CC(=C(C(=C1)O)N)C(=O)O

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PMID: # 23098234  Anal Chem. 10044-51.

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