3-Hydroxyanthranilic acid is a tryptophan metabolite along the kynurenine pathway. 3-Hydroxyanthranilic acid has been shown to induce apoptosis in T cells. In macrophages, 3-Hydroxyanthranilic acid has been shown to inhibit nitric oxide synthase and to stimulate TGF-β production.
1. Stone, T.W., Stoy, N., and Darlington, L.G.An expanding range of targets for kynurenine metabolites of tryptophan. Trends in Pharamacological Sciences 34(2), 136-143 (2013). 2. Thomas, S.R., Wittig, P.K., and Stocker, R.3-Hydroxyanthranilic acid is an efficient, cell-derived co-antioxidant for α-tocopherol, inhibiting human low density lipoprotein and plasma lipid peroxidation. The Journal of Biological Chemisty 271, 32714-32721 (1996).
Soluble in 1N HCl (10 mg/ml), water (partly), ether, chloroform, and alcohols.