Molecular structure of 2′-MeCCPA, CAS Number: 205171-12-6
2′-MeCCPA (CAS 205171-12-6)
Alternate Names:
2-Chloro-N-cyclopentyl-2′-methyladenosine
Application:
2′-MeCCPA is a potent and highly selective agonist at Adenosine A1-R
CAS Number:
205171-12-6
Purity:
≥98%
Molecular Weight:
383.83
Molecular Formula:
C16H22ClN5O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Potent and highly selective agonist at A1 adenosine receptors (Ki values are 3.3, 9580, 37600 and 1150 nM for human recombinant A1, A2A, A2B and A3 receptors respectively). Acts as a full agonist; inhibits forskolin-stimulated adenylyl cyclase activity in rat cortical membranes with an IC50 value of 13.1 nM.
2′-MeCCPA (CAS 205171-12-6) References
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- Reciprocal modulation of anti-IgE induced histamine release from human mast cells by A₁ and A(2B) adenosine receptors. | Yip, KH., et al. 2011. Br J Pharmacol. 164: 807-19. PMID: 21506953
- Aldehyde dehydrogenase type 2 activation by adenosine and histamine inhibits ischemic norepinephrine release in cardiac sympathetic neurons: mediation by protein kinase Cε. | Robador, PA., et al. 2012. J Pharmacol Exp Ther. 343: 97-105. PMID: 22761303
- Extracellular adenosine triphosphate affects the response of human macrophages infected with Mycobacterium tuberculosis. | Dubois-Colas, N., et al. 2014. J Infect Dis. 210: 824-33. PMID: 24604822
- Systemic inflammation regulates microglial responses to tissue damage in vivo. | Gyoneva, S., et al. 2014. Glia. 62: 1345-60. PMID: 24807189
- Adenosine Signaling Increases Proinflammatory and Profibrotic Mediators through Activation of a Functional Adenosine 2B Receptor in Renal Fibroblasts. | Wilkinson, PF., et al. 2016. Ann Clin Lab Sci. 46: 339-45. PMID: 27466291
- Adenosine from a biologic source regulates neutrophil extracellular traps (NETs). | Xu, K., et al. 2019. J Leukoc Biol. 105: 1225-1234. PMID: 30907983
- NanoBiT Complementation to Monitor Agonist-Induced Adenosine A1 Receptor Internalization. | Soave, M., et al. 2020. SLAS Discov. 25: 186-194. PMID: 31583945
- Agonists and Antagonists for Purinergic Receptors. | Müller, CE., et al. 2020. Methods Mol Biol. 2041: 45-64. PMID: 31646479
- Osmotic and hypoxic induction of osteopontin in retinal pigment epithelial cells: Involvement of purinergic receptor signaling. | Hollborn, M., et al. 2020. Mol Vis. 26: 188-203. PMID: 32214785
- G-Protein-Gated Inwardly Rectifying Potassium (Kir3/GIRK) Channels Govern Synaptic Plasticity That Supports Hippocampal-Dependent Cognitive Functions in Male Mice. | Djebari, S., et al. 2021. J Neurosci. 41: 7086-7102. PMID: 34261700
- In silico identification of A1 agonists and A2a inhibitors in pain based on molecular docking strategies and dynamics simulations. | Xu, G., et al. 2023. Purinergic Signal. 19: 87-97. PMID: 34677752
- 2'-C-Methyl analogues of selective adenosine receptor agonists: synthesis and binding studies. | Franchetti, P., et al. 1998. J Med Chem. 41: 1708-15. PMID: 9572897
Activator of:
Adenosine A Receptor, and Adenosine A1-R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2′-MeCCPA, 10 mg | sc-203469 | 10 mg | $255.00 |