2,3-Dihydro-3-(1H-indol-3-ylmethylene)-2-oxo-1H-indole-5-sulfonamide CAS: 181223-16-5
MF: C17H13N3O3S
MW: 339.37
A potent inhibitor of spleen tyrosine kinase (Syk).

2,3-Dihydro-3-(1H-indol-3-ylmethylene)-2-oxo-1H-indole-5-sulfonamide (CAS 181223-16-5)

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Application 2,3-Dihydro-3-(1H-indol-3-ylmethylene)-2-oxo-1H-indole-5-sulfonamide is a potent inhibitor of spleen tyrosine kinase (Syk)
CAS 등록번호: 181223-16-5
순도: 98%
분자량: 339.37
분자식: C17H13N3O3S
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* Refer to Certificate of Analysis for lot specific data (including water content).
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2,3-Dihydro-3-(1H-indol-3-ylmethylene)-2-oxo-1H-indole-5-sulfonamide is a potent small molecule inhibitor of Syk (spleen tyrosine kinase).


References

Pivniouk, V., et al.: J. Clin. Invest., 103, 1737 (1999), Clark, D., et al.: Drug Discov. Today, 5, 49 (2000), Sedlik, C., et al.: J. Immunol., 170, 846 (2003),

Physical State :
Solid
용해도 :
Soluble in DMSO, ethanol (Sparingly), and methanol (Sparingly).
저장 :
Store at -20° C
녹는점 :
>300° C
비등점 :
612.29° C at 760 mmHg (Predicted)
밀도 :
~1.5 g/cm3 (Predicted)
굴절률 :
n20D 1.76 (Predicted)
IC50 :
SYK: IC50 = 128 nM (human)
pK Values :
pKa: 9.84 (Predicted)
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
PubChem CID :
22978714
MDL Number :
MFCD09907828
SMILES :
C1=CC=C2C(=C1)C(=CN2)/C=C\\3/C4=C(C=CC(=C4)S(=O)(=O)N)NC3=O

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